Cancer and Metastasis Reviews

, Volume 12, Issue 1, pp 39–52 | Cite as

Autocrine factors, type IV collagenase secretion and prostatic cancer cell invasion

  • Mark E. Stearns
  • Mona Stearns
Article

Summary

Motility factors play a major role in tumor cell invasion and metastases. The biochemical properties of various motility factors; the receptor mediated mechanism of action; the role of microtubules; the potential influence of oncogenes; and the influence of motility factors on type IV collagenase secretion and invasion are discussed. We report on expression of a 70 kDa motility factor, termed invasion stimulating factor (ISF), in human prostatic PC-3 sublines. Boyden chamber chemotactic assays and measurements of type IV collagenase synthesis and secretion suggest that an ISF-receptor dependent mechanism influences tumor cell invasion and protease secretion. Taken together, the evidence that autocrine motility factors play an essential role in tumor cell invasion and metastases is compelling.

Key words

motility factors metastases type IV collagenase prostate cancer 
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Copyright information

© Kluwer Academic Publishers 1993

Authors and Affiliations

  • Mark E. Stearns
    • 1
  • Mona Stearns
    • 2
  1. 1.Medical College of PennsylvaniaPhiladelphiaUSA
  2. 2.Department of PathologyMedical College of PennsylvaniaPhiladelphiaUSA

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