Adrenergic regulation of haemoglobin oxygen affinity in rainbow trout red cells
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Adrenaline (initial concentration 5×10−6 M) caused an increase in haemoglobin oxygen affinity of rainbow trout red cells incubated in vitro in physiological saline. The increase was more pronounced at low than at high extracellular pH values. Adrenaline also induced an increase in intracellular pH, swelling of red cells and a metabolic decrease in cellular ATP concentration. The most important reason for increased oxygen affinity was the increase in intracellular pH resulting, to a great extent, from decreased concentration of impermeable polyanions, ATP and haemoglobin, in the cell. In addition, the decrease in cellular ATP concentration as such increases oxygen affinity of haemoglobin.
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