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Acta Neuropathologica

, Volume 54, Issue 2, pp 143–147 | Cite as

The pathology of experimental obstructive hydrocephalus

A scanning electron microscopic study
  • A. Torvik
  • A. E. Stenwig
  • I. Finseth
Original Works

Summary

Obstructive hydrocephalus was produced in 14-day old rabbits by injection of kaolin into the cisterna magna. The ependymal lining was studied by scanning electron microscopy.

Marked hydrocephalus was present 1 or 2 weeks after the kaolin injection. The ependymal lining adapted remarkably well to the rapid expansion by increasing the surface area of the ependymal cells. No breaks or denudement of the ependymal lining was observed except at the sites of ruptured ventricular synechiae. Generally, these findings confirm previous light and electron microscopic observations on the same model (Torvik et al. 1976; Torvik and Stenwig 1977). The results are discussed in relation to current theories concerning the pathophysiology of acute hydrocephalus.

Key words

Hydrocephalus Ependyma 

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References

  1. Bleier R, Cruce JAF (1975) Supraependymal cells in the third ventricle: Identification as resident phagocytes of the brain. Science 189:299–301Google Scholar
  2. Chamberlain JG (1973) Analysis of developing ependymal and choroidal surfaces in rat brains using scanning electron microscopy. Develop Biol 31:22–30Google Scholar
  3. Clark RD, Milhorat TH (1970) Experimental hydrocephalus. Part 3: Light microscopic findings in acute and subacute obstructive hydrocephalus in the monkey. J Neurosurg 32:400–413Google Scholar
  4. Collins P (1979) Experimental obstructive hydrocephalus in the rat: A scanning electron microscopic study. Neuropathol Appl Neurobiol 5:457–468Google Scholar
  5. De SN (1950) A study of the changes in the brain in internal hydrocephalus. J Pathol Bact 62:197–208Google Scholar
  6. Garfia A, Mestres P, Rascher K (1980) Trinitrophenol lesions of the ventricular wall: A SEM-TEM study. Scanning electron microscopy. Ill, SEM Inc., AMF O'Hare (Chic.), USAGoogle Scholar
  7. Go KG, Stokroos J, Blaauw EH, Zuiderveen F, Molenaar J (1976) Changes of the ventricular ependyma and choroid plexus in experimental hydrocephalus, as observed by scanning electron microscopy. Acta Neuropathol (Berl) 34:55–64Google Scholar
  8. Hochwald GM, Sahar A, Sadik AR, Ransohoff J (1969) Cerebrospinal fluid production and histological observations in animals with experimental obstructive hydrocephalus. Exp Neurol 25:190–199Google Scholar
  9. Kindberg L-A, Vasenius L, Talanti S (1977) The surface fine structure of the ependymal lining of the lateral ventricle in rats with hereditary hydrocephalus. Cell Tiss Res 179:121–129Google Scholar
  10. Ogata J, Hochwald GM, Cravioto H, Ransohoff J (1972) Light and electron microscopic studies of experimental hydrocephalus. Acta Neuropathol (Berl) 21:213–223Google Scholar
  11. Page RB (1975) Scanning electron microscopy of the ventricular system in normal and hydrocephalic rabbits. Preliminary report and atlas. J Neurosurg 42:646–664Google Scholar
  12. Page RB, Rosenstein JM, Leure-du Pree AE (1979a) The morphology of the ependyma overlying gray and white matter in the rabbit lateral ventricle. Anat Rec 194:67–82Google Scholar
  13. Page RB, Rosenstein JM, Dovey BJ, Leure-du Pree AE (1979b) Ependymal changes in experimental hydrocephalus. Anat Rec 194:83–104Google Scholar
  14. Peters A (1974) The surface fine structure of the choroid plexus and ependymal lining of the rat lateral ventricle. J Neurocytol 3:99–108Google Scholar
  15. Price DL, James AE, Sperber E, Strecker EP (1976) Communicating hydrocephalus. Cisternographic and neuropathologic studies. Arch Neurol 33:15–20Google Scholar
  16. Torvik A, Bhatia R, Nyberg-Hansen R (1976) The pathology of experimental obstructive hydrocephalus. Neuropathol Appl Neurobiol 2:41–52Google Scholar
  17. Torvik A, Stenwig AE (1977) The pathology of experimental obstructive hydrocephalus. Electron microscopic observations. Acta Neuropathol (Berl) 38:21–26Google Scholar
  18. Weller RO, Wisniewski H, Shulman K, Terry RD (1971) Experimental hydrocephalus in young dogs: Histological and unltrastructural study of the brain tissue damage. J Neuropathol Exp Neurol 30:613–626Google Scholar
  19. Weller RO, Mitchell J, Griffin RL, Gardner MJ (1978) The effects of hydrocephalus upon the developing brain. Histological and quantitative studies of the ependyma and subependyma in hydrocephalic rats. J Neurol Sci 36:383–402Google Scholar
  20. Westergaard (1970) The lateral ventricles and the ventricular walls. Andelsbogtrykkeriet, Odense, DenmarkGoogle Scholar

Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • A. Torvik
    • 1
    • 2
  • A. E. Stenwig
    • 1
    • 2
  • I. Finseth
    • 1
    • 2
  1. 1.Laboratory of NeuropathologyUlleval HospitalOslo 1Norway
  2. 2.Department of PathologyThe Norwegian Radium HospitalOslo 3Norway

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