Cancer Chemotherapy and Pharmacology

, Volume 27, Issue 2, pp 94–100

Inflammatory carcinoma of the breast: results of a combined-modality approach — M. D. Anderson Cancer Center experience

  • Eun H. Koh
  • Aman U. Buzdar
  • Frederick C. Ames
  • S. Eva Singletary
  • Marsha D. McNeese
  • Debra Frye
  • Frankie Ann Holmes
  • Giuseppe Fraschini
  • Verena Hug
  • Richard L. Theriault
  • Charles M. Balch
  • Gabriel N. Hortobagyi
Original Articles Inflammatory Carcinoma, Combined Modality Treatment, Chemotherapy

DOI: 10.1007/BF00689090

Cite this article as:
Koh, E.H., Buzdar, A.U., Ames, F.C. et al. Cancer Chemother. Pharmacol. (1990) 27: 94. doi:10.1007/BF00689090

Summary

A total of 106 patients with inflammatory carcinoma of the breast underwent combined-modality treatment consisting of doxorubincin-containing chemotherapy. All patients received three cycles of 5-fluorouracil, doxorubicin, and cyclophosphamide (FAC) before local therapy. From 1974 to 1977 (group A), primary radiotherapy was the local treatment modality and chemotherapy was given for a total of 24 months. From 1978 to 1981 (group B), mastectomy became the primary local treatment modality and FAC was reinstituted within 10–14 days after surgery; after completion of FAC, consolidation radiotherapy was given. From 1982 to 1986 (group C), vincristine and prednisone were added to FAC, and doxorubicin was given by continuous infusion. The median follow-up of the three groups was 56 months. For patients alive at the time of analysis, median follow-ups were 141, 111, and 49 months in groups A, B, and C, respectively. Disease-free survival at 5 years was 35%, 22%, and 41% for groups A, B, and C, respectively, and respective overall survival at 5 years was 37%, 30%, and 48%. Mastectomy in addition to radiotherapy resulted in local control rates similar to those obtained with radiotherapy alone, but this approach would result in fewer late sequelae of high-dose irradiation and provided histologic staging for chemotherapy response. The patients treated on protocol C had slightly better disease-free and overall survival, but the differences were not statistically significant. The 5-year disease-free survival of patients achieving a clinical complete remission (CR) or partial remission (PR) was superior to that of patients whose response was less than a PR. There was no episode of doxorubicin-related cardiac toxicity in group C. Combined-modality treatment for inflammatory carcinoma of the breast resulted in improved survival.

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • Eun H. Koh
    • 1
  • Aman U. Buzdar
    • 1
  • Frederick C. Ames
    • 3
  • S. Eva Singletary
    • 3
  • Marsha D. McNeese
    • 2
  • Debra Frye
    • 1
  • Frankie Ann Holmes
    • 1
  • Giuseppe Fraschini
    • 1
  • Verena Hug
    • 1
  • Richard L. Theriault
    • 1
  • Charles M. Balch
    • 3
  • Gabriel N. Hortobagyi
    • 1
  1. 1.Department of Medical Oncology, Medical BreastThe University of Texas M. D. Anderson Cancer CenterHoustonUSA
  2. 2.Department of RadiotherapyThe University of Texas M. D. Anderson Cancer CenterHoustonUSA
  3. 3.Department of SurgeryThe University of Texas M. D. Anderson Cancer CenterHoustonUSA

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