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Acta Neuropathologica

, Volume 8, Issue 3, pp 276–284 | Cite as

Fine structural localization of acid phosphatase in senile plaques in Alzheimer's presenile dementia

  • Kinuko Suzuki
  • Robert D. Terry
Article

Summary

Submicroscopic localization of acid phosphatase activity within the senile plaques was studied in two cases of Alzheimer's presenile dementia. The enzymatic activity seen in the plaque seems to be largely localized within the dense bodies in the distended axons and dendrites. The lysosomal nature of these bodies is, therefore, suggested. On the basis of striking morphological and histochemical resemblance of the changes seen in axons and dendrites in senile plaques to those seen in early Wallerian degeneration, formation of the plaque is hypothesized as secondary to a proximal degeneration in the neuronal perikaryon, possibly related to the neurofibrillary tangle of Alzheimer.

Keywords

Enzymatic Activity Dementia Phosphatase Activity Acid Phosphatase Structural Localization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Zusammenfassung

Die submikroskopische Lokalisation der sauren Phosphatase-Aktivität in senilen Plaques wurde bei zwei Fällen von Alzheimers präseniler Demenz untersucht. Die in den Plaques vorhandene Enzymaktivität scheint hauptsächlich innerhalb der “dense bodies” in den erweiterten Axonen und Dendriten lokalisiert zu sein. Die lysosomale Natur dieser Körperchen ist daher anzunehmen. Auf Grund der offenbaren morphologischen und histochemischen Ähnlichkeit der Veränderungen in Axonen und Dendriten von senilen Plaques mit denen in Frühstadien der Wallerschen Degeneration wird die Bildung der Plaques hypothetisch als Sekundärfolge einer proximalen Degeneration des neuronalen Perikaryons in möglicher Beziehung zur Alzheimerschen Neurofibrillenveränderung angenommen.

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References

  1. Agostini, L.: La reazione istochimica della fosfatasi acida nelle plache senili. Proc. Internat. Congr. Neuropath, Rome11, pp. 395–397 (1952).Google Scholar
  2. Alzheimer, A.: Über eine eigenartige Erkrankung der Hirnrinde. Zbl. Nervenh. Psychiat.18, 177–179 (1907).Google Scholar
  3. Andres, K. H.: Elektronenmikroskopische Untersuchungen über Strukturveränderungen an den Nervenfasern in Rattenspinalganglien nach Bestrahlung mit 185 Met-Protonen. Z. Zellforsch.61, 1–22 (1963).Google Scholar
  4. Divry, P.: De la Nature de l'Alteration Fibrillaire d'Alzheimer. J. belge Neurol. Psychiat.34, 197–201 (1934).Google Scholar
  5. Friede, R. L.: Enzyme histochemical studies of senile plaques. J. Neuropath. exp. Neurol.24, 477–491 (1965).Google Scholar
  6. — andK. R. Magee: Alzheimer's Disease—presentation of a case with pathologic and enzymatic histochemical observation. Neurology (Minneap.)12, 213–222 (1962).Google Scholar
  7. Gomori, G.: An improved histochemical technic for acid phosphatase. Stain Technol.25, 81–85 (1950).Google Scholar
  8. Holtzman, E., andA. B. Novikoff: Lysosomes in the rat sciatic nerve following crush. J. Cell Biol.27, 651–669 (1965).Google Scholar
  9. Josephy, H.: Acid phosphatase in the senile brain. Arch. Neurol. Psychiat. (Chic.)61, 164–169 (1949).Google Scholar
  10. Janigan, D. T.: The effect of aldehyde fixation on acid phosphatase activity in tissue block. J. Histochem. Cytochem.13, 476–483 (1965).Google Scholar
  11. Kidd, M.: Alzheimer's Disease—an electron-microscopic study. Brain87, 307–320 (1964).Google Scholar
  12. Krigman, M. R., R. G. Feldman, andK.Bensch: Alzheimer's presenile dementia—a histochemical and electronmicroscopic study. Lab. Invest.14, 381–396 (1965).Google Scholar
  13. Lampert, P., andM. Cressman: Axonal regeneration in the dorsal column of the spinal cord of adult rat. Lab. Invest.13, 825–839 (1964).Google Scholar
  14. Luse, S., andK. R. Smith: The ultrastructure of senile plaques. Amer. J. Path.44, 453–463 (1964).Google Scholar
  15. Morel, F., andE. Wildi: General and cellular pathochemistry of senile and presenile alterations of the brain. Proc. Internat. Congr. Neuropath., Rome11, pp. 374–377 (1952).Google Scholar
  16. Porter, K. P., N. Kawakami, andM. C. Ledbetter: Structural basis of streaming in Physarum Polycephalum. J. Cell Biol.27, 78 A (Abstract) (1965).Google Scholar
  17. Tani, E.: Electronmicroscopic study on Wallerian degeneration of optic nerve. J. Neuropath. exp. Neurol.23, 162 (Abstract) (1964).Google Scholar
  18. Robbins, E., andN. K. Gonatas: The ultrastructure of a mammalian cell during the mitotic cycle. J. Cell Biol.21, 429–463 (1964).Google Scholar
  19. Terry, R. D.: The fine structure of neurofibrillary tangles in Alzheimer's disease. J. Neuropath. exp. Neurol.22, 629–642 (1963).Google Scholar
  20. N. K. Gonatas andM. Weiss: Ultrastructural studies in Alzheimer's presenile dementia. Amer. J. Path.44, 269–297 (1964).Google Scholar
  21. —, andC. Pena: Experimental production of neurofibrillary degeneration. 2. Electronmicroscopy. Phosphatase histochemistry and electron probe analysis. J. Neuropath. exp. Neurol.24, 200–210 (1965).Google Scholar
  22. —, andM. Weiss: Studies in Tay-Sachs disease 1. A Methods. 2. Electron microscopic. J. Neuropath. exp. Neurol.22, 2–4 (1963).Google Scholar
  23. Wallace, B. J., B. W. Volk, L. Schneck, andH. Kaplan: Fine structural localization of two hydrolytic enzymes in the cerebellum of children with lipidosis. J. Neuropath. exp. Neurol.25, 76–96 (1965).Google Scholar
  24. Webster, H. D.: Transient, focal accumulation of axonal mitochondria during the early stages of Wallerian degeneration. J. Cell Biol.12, 361–383 (1962).Google Scholar
  25. Weiss, P.: Nerve regeneration in the rat following tubular splicing of severed nerve. Arch. Surg.46, 525–547 (1943).Google Scholar

Copyright information

© Springer-Verlag 1967

Authors and Affiliations

  • Kinuko Suzuki
    • 1
  • Robert D. Terry
    • 1
  1. 1.Department of Pathology (Neuropathology)Albert Einstein College of MedicineNew YorkUSA

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