Acta Neuropathologica

, Volume 58, Issue 4, pp 255–260

The Onuf's nucleus and the external anal sphincter muscles in amyotrophic lateral sclerosis and Shy-Drager syndrome

  • T. Mannen
  • M. Iwata
  • Y. Toyokura
  • K. Nagashima
Original Works

Summary

The anterior sacral horns and external anal sphincter muscle were examined histologically with special reference to Onuf's nucleus in amyotrophic lateral sclerosis (ALS) and Shy-Drager syndrome. Onuf's nucleus and the external anal sphincter muscles were well preserved in ALS, but in Shy-Drager syndrome both structures showed marked degenerative changes. These findings suggest that Onuf's nucleus does not belong to the autonomic neurons, but to the motoneurons in anterior sacral horn, and it innervates the external sphincter muscles of the anus and urethra.

Key words

Onuf's nucleus Sphincter muscles ALS Shy-Drager syndrome 

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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • T. Mannen
    • 2
  • M. Iwata
    • 2
  • Y. Toyokura
    • 2
  • K. Nagashima
    • 1
  1. 1.Department of Pathology, Faculty of MedicineUniversity of TokyoBunkyo-ku, TokyoJapan
  2. 2.Dept. of Neurology, Institute of Brain Research, Faculty of MedicineUniversity of TokyoBunkyo-ku, TokyoJapan

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