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Acta Neuropathologica

, Volume 21, Issue 3, pp 179–184 | Cite as

Blood-brain barrier dysfunction in experimental mercury intoxication

  • Louis W. Chang
  • Henrik A. Hartmann
Original Investigations

Summary

Methylmercuric chloride (CH3HgCl) or mercuric bichloride (HgCl2) were administered to the rats at a dosage of 1.0 mg/kg body weight. Toluidine blue-albumin was injected into these animals at various periods after the intoxication. Leakage of the dye into the nervous parenchyma was observed as early as 12 h after the intoxication indicating an impairment and dysfunction of the blood-brain barrier. This dysfunction is believed to be due to an impairment of the endothelial and glial membranes by the mercury.

Key words

Mercury Poisoning Rats Blood-Brain Barrier Extravasation Dye Penetration 

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Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • Louis W. Chang
    • 1
  • Henrik A. Hartmann
    • 1
  1. 1.Department of PathologyUniversity of Wisconsin Med. SchoolMadisonU.S.A

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