Correlation of structure and function in selected tumors of the human nervous system
- 14 Downloads
Summary
Tumors of the human cranio-spinal axis and its nerves have been studied under the electron microscope. An attempt was made to correlate the ultrastructural characteristics with the biological activity of these tumors and to use this as a basis upon which identity of individual neoplastic elements may be identified. Specifically, the role of optic tract glioma cells in myelinogenesis, of neoplastic astrocytes in pinocytosing RISA, and of perineurial fibroblastoma cells in synthesizing, storing, and secreting collagen was discussed.
Keywords
Public Health Collagen Electron Microscope Nervous System Biological ActivityZusammenfassung
Tumoren des zentralen und peripheren Nervensystems des Menschen wurden elektronenoptisch untersucht. Es wurde der Versuch einer Korrelation der ultrastrukturellen Merkmale mit der biologischen Aktivität dieser Geschwülste sowie deren Anwendung als Grundlage zur Identifikation einzelner Fremdgewebselemente unternommen. Besondere Berücksichtigung fanden die Bedeutung der Zellen von Opticusgliomen für die Myelogenese, die Rolle neoplastischer Astrocyten in der Pinocytose von RISA sowie die Bedeutung der Zellen perineuraler Fibroblastome für die Synthese, Speicherung und Sekretion von Kollagen.
Preview
Unable to display preview. Download preview PDF.
Bibliography
- Bennett, H. S.: Concepts of membrane flow and membrane fasciculation as mechanism for active transport and ion pumping. J. biophys. biochem. Cytol.24, 99–103 (1956).Google Scholar
- Brandt, P. W., andG. P. Pappas: Electron-microscopic study of pinocytosis in ameda: II. Cytoplasmic uptake phase. J. Cell. Biol.15, 55–71 (1962).Google Scholar
- DiChiro, G.: RISA encephalography and conventional neuroradiologic methods. A comparative study. Acta radiol. (Stockh.) Suppl. 201 (1961).Google Scholar
- Geren, B. B.: The formation from the Schwann cell surface of myelin in the peripheral nerves of chick embryos. Exp. Cell. Res.7, 558–561 (1954).Google Scholar
- Goldberg, B., andH. Green: An analysis of collagen secretion by established mouse fibroblast lines. J. Cell. Biol.22, 227–258 (1964).Google Scholar
- Nathaniel, E. J. H., andD. C. Pease: Collagen and basement membrane formation by Schwann cells during nerve regeneration. J. Ultrastruct. Res.9, 550–560 (1963).Google Scholar
- Movat, H., andN. V. P. Fernando: The fine structure of connective tissue. I. The fibroblast. Exp. Mol. Path.1, 509–534 (1964).Google Scholar
- Pineda, A.: Collagen formation by principal cells of acoustic tumors. Neurology (Minneap.)15, 536–547 (1965).Google Scholar
- Raimondi, A. J.: Localization of radio-iodinated serum albumin in human glioma. Arch. Neurol. (Chic.)11, 173–184 (1964).Google Scholar
- —J. P. Evans, andS. Mullan: Studies of cerebral edema III. Alterations in the white matter: An electron-microscopic study using ferritin as a labeling compound. Acta neuropath. (Berl.)2, 177–197 (1962).Google Scholar
- Ross, R., andE. P. Benditt: Wound healing and collagen formation. I. Sequential changes in components of guinea pig skin wounds observed in the electron microscope. J. biophys. biochem. Cytol.11, 677–700 (1961).Google Scholar
- Thomas, P. K.: The deposition of collagen in relation to Schwann cell basement membrane during peripheral nerve regeneration. J. Cell Biol.23, 375–381 (1964).Google Scholar