Acta Neuropathologica

, Volume 16, Issue 2, pp 117–124

The effect of acute arterial hypertension on the blood-brain barrier to protein tracers

  • Barbro Johansson
  • Choh-Luh Li
  • Yngve Olsson
  • Igor Klatzo
Original Investigations


A study was made on the effect of acute hypertension on the blood-brain barrier to proteins. The arterial blood pressure was raised by intravenous injections of metaraminol bitartrate (Aramine) and Evans Blue was used as protein tracer.

Multiple foci Evans Blue extravasation became evident in the gray matter of the brain as early as 10 min after the sudden increase of blood pressure by 90 mm Hg or higher. As observed under the fluorescence microscope, the tracer had penetrated the walls of intracerebral vessels and accumulated in numerous adjacent neurons. EEG recordings from blue stained areas of the cerebral cortex showed changes in neuronal activity.


Arterial Hypertension Blood-Brain Barrier Protein Tracers 


Die Wirkung akuter Hypertension auf die Blut-Hirnschranke für Proteine wurde untersucht. Die arterielle Blutdrucksteigerung wurde durch. i.v. Verabreichung von Metaraminol-bitartrat (Aramine®) erzeugt. Als Schrankenindikator wurde Evansblau verwendet.

Multiple Herde von Evansblau-Extravasaten fanden sich in der grauen Hirnsubstanz frühestens 10 min nach plötzlicher Steigerung des Blutdruckes um 90 mm Hg oder höher. Fluorescenzoptische Untersuchungen ergaben, daß der Indicator durch die Wand der intracerebralen Gefäße ausgetreten war und sich in zahlreichen benachbarten Nervenzellen angesammelt hatte. EEG-Ableitungen der blau angefärbten Rindenareale ergaben Veränderungen der neuronalen Aktivität.


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Copyright information

© Springer-Verlag 1970

Authors and Affiliations

  • Barbro Johansson
    • 1
    • 3
  • Choh-Luh Li
    • 1
  • Yngve Olsson
    • 1
    • 2
    • 4
  • Igor Klatzo
    • 1
  1. 1.Laboratory of Neuropathology and Neuroanatomical Sciences and Surgical Neurology Branch National Institute of Neurological Diseases and StrokeNational Institutes of HealthBethsedaUSA
  2. 2.Institute of PathologyGöteborgSweden
  3. 3.Department of NeurologyUniversity of GöteborgSweden
  4. 4.Institute of PathologyUniversity of GöteborgSweden

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