Acta Neuropathologica

, Volume 51, Issue 3, pp 237–239 | Cite as

Polysaccharide accumulation in the central nervous system ofd-penicillamine-treated rats

  • A. Paul Jayaraj
Short Original Communications
Received:
Accepted:

Summary

A complex polysaccharide accumulation was observed in the central nervous system (CNS) of rats treated withd-penicillamine similar to Lafora-like bodies. They have histochemical similarities comparable to bodies described in previous studies of Lafora disease. The clinical usefulness ofd-penicillamine has been limited by many side effects including renal damage. It is suggested that, in addition tod-penicillamine nephropathy, there are toxic effects of this drug on the CNS.

Key words

Polysaccharide d-penicillamine Lafora-like bodies Nephropathy 
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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • A. Paul Jayaraj
    • 1
  1. 1.Department of Surgery, The Rayne InstituteUniversity College Hospital Medical SchoolLondonUK

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