Acta Neuropathologica

, Volume 63, Issue 4, pp 296–300

Immuno-electron-microscopic localization of complements in amyloid fibrils of senile plaques

  • T. Ishii
  • S. Haga
Original Works


The presence of components of immunoglobulins (Ishii et al. 1975) and complements (Eikelenboom and Stam 1982) in senile plaques suggests that the immunologic mechanisms are involved in the causation of pathologic processes in the brain of patients with Alzheimer's disease. Senile plaques consists of amyloid degenerated neuritis and glia, and exact localization of complements among these tissue elements will provide an important clue to the pathogenesis of the Alzheimer brain. This report deals with light- and electronmicroscopic localization of complements in amyloid fibrils of senile plaques by immunoperoxidase histochemistry. The presence of C1q, C4, and C3 is confirmed light-microscopically. At the ultrastructural level, anti-complement C1q, C4, and C3 peroxidase reaction products are exclusively localized on the amyloid fibrils, but no other tissue elements, such as normal or degenerated neurites, neurofibrillary tangles, or glia. The results indicate the presence of immune complex in amyloid fibrils of senile plaques, and little association of complements in senile plaques with neurofilament protein.

Key words

Alzheimer's disease Senile plaque Amyloid Complement Immuno-electron microscopy 


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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • T. Ishii
    • 1
  • S. Haga
    • 1
  1. 1.Division of Ultrastructure and HistochemistryPsychiatric Research Institute of TokyoSetagaya-ku, TokyoJapan

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