Acta Neuropathologica

, Volume 27, Issue 2, pp 171–176 | Cite as

Neurological changes in cats following long-term diet of mercury contaminated tuna

  • Louis W. Chang
  • Seiya Yamaguchi
  • Alden W. DudleyJr.
Short Original Communications


Young kittens of both sexes were fed daily with mercury contaminated tuna (containing about 0.5 ppm mercury). Neurological disturbances similar to those in Minamata disease or in experimental mercury intoxication (ataxia, weakness and incoordination of movements) were observed after 7–11 months of the experimental course. Microscopic examination revealed degenerations of the granular layer and some Purkinje neurons in the cerebellum. Neuronal necrosis was also observed in the cerebral cortex. The present investigation suggests that fish containing 0.5 ppm mercury (U.S. Food and Drug Administration approved level) may still be potentially hazardous to health when consumed in excessive amounts for prolonged periods of time.

Key words

Mercury Poisoning Contaminated Fish Neuronal Changes Neurological Disturbances 


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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • Louis W. Chang
    • 1
    • 2
  • Seiya Yamaguchi
    • 1
    • 2
  • Alden W. DudleyJr.
    • 1
    • 2
  1. 1.Department of PathologyUniversity of WisconsinMadisonUSA
  2. 2.Department of Public HealthKurume UniversityKurumeJapan

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