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Cancer Chemotherapy and Pharmacology

, Volume 31, Supplement 1, pp S157–S161 | Cite as

Liver transplantation for hepatocellular carcinoma: clinical results and future aspects

  • Rudolf Pichlmayr
  • Arved Weimann
  • Gustav Steinhoff
  • Burckhardt Ringe
Plenary Session: State of the Art in Liver Cancer HBV, HCV Hepatocellular Carcinoma

Summary

The treatment of unresectable hepatocellular carcinoma (HCC) by liver transplantation remains controversial. In our series, the 5-year survival value for 87 patients who underwent transplantations between 1972 and 1990 was 19.6%. There was no difference in the longterm survival of patients who had underlying cirrhosis and those who did not. In patients with early-stage tumours the long-term prognosis was improved, the 5-year survival in stage II disease being 55.6% according to UICC criteria. Even in some cases of more advanced tumour stage, good long-term results were obtained. In a review of the recent literature, we evaluated prognostic factors to work out criteria for a more differentiated indication for liver transplantation. Resection of increased radicality-which will keep its place as the therapy of choice — and transplantation should be performed complementarily. Further developments will reveal the value of multimodal therapeutic strategies, including chemo-embolisation, chemotherapy and immunotherapy.

Keywords

Carcinoma Clinical Result Prognostic Factor Hepatocellular Carcinoma Liver Transplantation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • Rudolf Pichlmayr
    • 1
  • Arved Weimann
    • 1
  • Gustav Steinhoff
    • 1
  • Burckhardt Ringe
    • 1
  1. 1.Klinik für Abdominal- and TransplantationschirurgieMedizinische Hochschule HannoverHannover 61Germany

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