Cancer Chemotherapy and Pharmacology

, Volume 31, Supplement 1, pp S35–S37 | Cite as

Results of hepatic resection and postoperative arterial chemotherapy for hepatocellular carcinoma

  • Akio Harada
  • Toshiaki Nonami
  • Wakahiko Kishimoto
  • Akimasa Nakao
  • Hiroshi Takagi
Session I: Treatment for Operable Patients Surgery and Combined Modalities Hepatocellular Carcinoma, Hepatic Resection, Hepatic Arterial Chemotherapy

Summary

To improve the outcome of patients who had undergone hepatic resection for hepatocellular carcinoma (HCC), we employed postoperative adjuvant hepatic arterial infusion chemotherapy (AHAI) in 23 patients. Patients showing various risk factors for the recurrence of HCC were given one shot of doxorubicin and mitomycin C suspended in an oily medium (lipiodol) and an infusion of 5-fluorouracil. The 3-year survival value calculated for patients who were treated with AHAI was 75%, which was significantly higher than that found for patients who did not receive AHAI (n=156;P<0.05). In addition, among the patients who underwent hepatic lobectomy, the survival of those who received AHAI was also significantly greater than that of those who did not (n=46;P<0.01). AHAI did not cause any severe complications. These results indicate that AHAI may be an effective therapy for patients with HCC.

References

  1. 1.
    Konno T, Maeda H, Iwaki K, Maki S, Tashiro S, Uchida M, Miyauchi Y (1984) Selective targetting of anticancer drug and simultaneous image enhancement in solid tumors by arterially administered lipid contrast medium. Cancer 54:2367Google Scholar
  2. 2.
    Lin TY, Lee CS, Chen KM, Chen CC (1987) Role of surgery in the treatment of primary carcinoma of the liver: a 31-year experience. Br J Surg 74:839Google Scholar
  3. 3.
    Liver Cancer Study Group of Japan (1989) The general rules for the clinical and pathological study of primary liver cancer. Jpn J Surg 19:98Google Scholar
  4. 4.
    Makuuchi M, Hasegawa H, Yamazaki S (1985) Ultrasonically guided subsegmentectomy. Surg Gynecol Obstet 161:346Google Scholar
  5. 5.
    Nagao T, Inoue S, Yoshimi F, Sodeyama M, Omori Y, Mizuta T, Kawano N, Morioka Y (1990) Postoperative recurrence of hepatocellular carcinoma. Ann Surg 211:28Google Scholar
  6. 6.
    Nonami T, Takagi H (1989) The role of hepatic arterial infusion chemotherapy for hepatoma. Jpn J Gastroenterol 86:1885Google Scholar
  7. 7.
    Nonami T, Isshiki K, Katoh H, Kishimoto W, Harada A, Nakao A, Takagi H (1991) The potential role of postoperative hepatic artery chemotherapy in patients with high-risk hepatomas. Ann Surg 213: 222Google Scholar
  8. 8.
    Reed ML, Vaitkevicius VK, Al-Sarraf M, Vaughn CB, Singhakowinta A, Sexon-Porte M, Izbicki R, Baker L, Straatsma GW (1981) The practicality of chronic hepatic artery infusion therapy of primary and metastatic hepatic malignancies: ten-year results of 124 patients in a prospective protocol. Cancer 47:402Google Scholar
  9. 9.
    Shibata J, Fujiyama S, Sato T, Kishimoto S, Fukushima S, Nakano M (1989) Hepatic arterial injection chemotherapy with cisplatin suspended in an oily lymphographic agent for hepatocellular carcinoma. Cancer 64:1586Google Scholar
  10. 10.
    Tanaka S, Kitamura T, Nakanishi K, Okuda S, Kojima J, Fujimoto I (1989) Recent advances in ultrasonographic diagnosis of hepatocellular carcinoma. Cancer 63:1313Google Scholar

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • Akio Harada
    • 1
  • Toshiaki Nonami
    • 1
  • Wakahiko Kishimoto
    • 1
  • Akimasa Nakao
    • 1
  • Hiroshi Takagi
    • 1
  1. 1.Department of Surgery IINagoya University School of MedicineNagoyaJapan

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