Cancer Chemotherapy and Pharmacology

, Volume 31, Supplement 1, pp S7–S12 | Cite as

Clinicopathological study on combination therapy consisting of arterial infusion of lipiodol-dissolved SMANCS and transcatheter arterial embolization for hepatocellular carcinoma

  • Kenji Jinno
  • Shosuke Moriwaki
  • Minoru Tanada
  • Toshihiro Wada
  • Koichi Mandai
  • Yoshio Okada
Session I: Treatment for Operable Patients Surgery and Combined Modalities Hepatocellular Carcinoma, Lipiodol Transcatheter Arterial Embolizatior


Combination therapy (LpTAE) consisting of arterial infusion of a lipophilic anticancer drug, SMANCS, dissolved in an oily lymphographic agent, lipiodol (LPD), and transcatheter arterial embolization (TAE) for hepatocellular carcinoma (HCC) was studied with special reference to the pathological findings. A total of 32 patients were subjected to surgical resection after LpTAE. The pattern of LPD deposition in the tumor was examined by CT scan (Lipiodol CT, LpCT) at 7 days and/or 1 month after LpTAE. The resected materials were examined radiographically with soft X-rays and histologically. LPD was deposited in tiny daughter nodules with a diameter of less than 5 mm and in tumor thrombi as well as in the main tumors, which showed necrotic change. Part of the LPD flowed out from the main tumor via the drainage vein and was deposited in the capsular invasion, resulting in necrosis. LPD accumulated almost exclusively within the blood spaces of trabecular-type HCC, creating a pattern corresponding to a cast of the tumor vessels, which showed prominent necrossi. On the other hand, LPD was not deposited in scirrhous, compact, or well-differentiated HCC, which showed little or no necrosis. It was demonstrated that LpCT images, which accurately depicted the existence and the extent of LPD deposition and necrosis in peutic effect. Our findings indicate that LpTAE and LpCT are valuable for the diagnosis and treatment of HCC and should play a central role in systemic therapeutic approaches to this disease.


Hepatocellular Carcinoma Surgical Resection Anticancer Drug Pathological Finding Tumor Thrombus 
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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • Kenji Jinno
    • 1
  • Shosuke Moriwaki
    • 3
  • Minoru Tanada
    • 2
  • Toshihiro Wada
    • 1
  • Koichi Mandai
    • 3
  • Yoshio Okada
    • 4
  1. 1.Department of Internal MedicineShikoku Cancer Center HospitalMatsuyamaJapan
  2. 2.Department of SurgeryShikoku Cancer Center HospitalMatsuyamaJapan
  3. 3.Department of PathologyShikoku Cancer Center HospitalMatsuyamaJapan
  4. 4.Okayama Prefectural Junior CollegeOkayamaJapan

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