Cancer Chemotherapy and Pharmacology

, Volume 33, Supplement 1, pp S149–S152 | Cite as

A randomized trial of intrahepatic arterial infusion of 4′-epidoxorubicin with Lipiodol versus 4′-epidoxorubicin alone in the treatment of hepatocellular carcinoma

  • Masaharu Yoshikawa
  • Hiromitsu Saisho
  • Masaaki Ebara
  • Toshihiko Iijima
  • Shosuke Iwama
  • Fumio Endo
  • Michio Kimura
  • Yoshiyuki Shimamura
  • Yasutoshi Suzuki
  • Toshihiko Nakano
  • Yoshio Fukuyama
  • Kiyotaka Fujise
  • Masaji Nambu
  • Masao Ohto
Clinical Aspects in the Treatment for Operable and Session II. Chemotherapy and Radiotherapy II. 3. Reservoir and Others Hepatocellular Carcinoma, Chemotherapy, Liiodol

Abstract

We conducted a prospective randomized trial to evaluate the efficacy of Lipiodol in intrahepatic arterial infusion chemotherapy for patients with hepatocellular carcinoma (HCC). A total of 38 patients with unresectable HCCs and underlying cirrhosis were entered in this trial, and 36 of them were evaluable. Every 4 weeks, 17 patients received 70 mg of 4′-epidoxorubicin (epirubicin) alone (group A), whereas 19 patients received a Lipiodol emulsion containing the same dose of epirubicin (group B) through the hepatic artery. A tumor response (CR+PR) was observed in 12% of group A patients and in 42% of group B patients. The group B patients showed a significantly higher response rate than the group A patients. There was a tendency for an increased duration of survival (P=0.09) in the group B patients. These results suggested that the infusion of the Lipiodol emulsion with epirubicin was more effective than epirubicin alone for the treatment of these patients with HCC.

Keywords

Carcinoma Cancer Research Hepatocellular Carcinoma Randomized Trial Hepatic Artery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • Masaharu Yoshikawa
    • 10
  • Hiromitsu Saisho
    • 10
  • Masaaki Ebara
    • 10
  • Toshihiko Iijima
    • 1
  • Shosuke Iwama
    • 2
  • Fumio Endo
    • 3
  • Michio Kimura
    • 4
  • Yoshiyuki Shimamura
    • 5
  • Yasutoshi Suzuki
    • 6
  • Toshihiko Nakano
    • 7
  • Yoshio Fukuyama
    • 8
  • Kiyotaka Fujise
    • 9
  • Masaji Nambu
    • 1
  • Masao Ohto
    • 10
  1. 1.Division of Internal MedicineJuntendo University Urayasu HospitalUrayasuJapan
  2. 2.Division of Internal MedicineChiba Rosai HospitalChibaJapan
  3. 3.Department of SurgeryMatsudo Municipal HospitalMatsudoJapan
  4. 4.Division of Internal MedicineChiba Kaihin Municipal HospitalChibaJapan
  5. 5.Department of SurgeryChiba West HospitalChibaJapan
  6. 6.Division of Internal MedicineFunabashi Municipal Medical CenterFunabashiJapan
  7. 7.Division of Internal MedicineSocial Insurance Funabashi Central HospitalFunabashiJapan
  8. 8.Division of Internal MedicineKimitsu Central HospitalKimitsuJapan
  9. 9.Department of General Internal MedicineJikei University, School of MedicineTokyoJapan
  10. 10.First Department of MedicineChiba University, School of MedicineChibashi, ChibaJapan

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