Acta Neuropathologica

, Volume 76, Issue 5, pp 451–457 | Cite as

Cerebrovascular lesions in acquired immune deficiency syndrome (AIDS)

  • H. Mizusawa
  • A. Hirano
  • J. F. Llena
  • M. Shintaku
Regular Papers


Cerebrovascular lesions were seen in 28 of 83 cases (34%) of acquired immune deficiency syndrome (AIDS). Cerebral hemorrhage was noted in 4 cases, cerebral infarct in 23 cases and both in 1 case. Cerebral hemorrhage was in various locations such as intraparenchymal, subarachnoid space, subdural space and epidural space. Large, clinically evident hemorrhage was noted in 2 of 5 cases and bleeding tendency was noted in 2 cases. Most of the 24 cases with cerebral infarcts were not clinically evident; they were multiple, small and mainly involved the striatum, cerebral cortex and brain stem. Mural thickening of occasional small blood vessels was seen in 12 of the cases (50%) with infarcts. Other changes in blood vessels included vasculitis in one cases and perivascular lymphocytic infiltration in another. In addition to thrombo-embolism and systemic ischemia/anoxia, these blood vessel changes may have a role in the development of cerebral infarcts in AIDS.

Key words

AIDS Cerebral hemorrhage Cerebral infarct Mural thickening of small blood vessels 


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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • H. Mizusawa
    • 1
  • A. Hirano
    • 1
  • J. F. Llena
    • 1
  • M. Shintaku
    • 1
  1. 1.Bluestone Laboratory Division of Neuropathology, Department of PathologyMontefiore Medical CenterBronxUSA

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