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Acta Neuropathologica

, Volume 75, Issue 6, pp 627–631 | Cite as

Ceroid-lipofuscinosis in Border Collie dogs

  • R. M. Taylor
  • B. R. H. Farrow
Regular Papers

Summary

Five Border Collie dogs with ceroid-lipofuscinosis developed progressive neurological disease between 18 and 22 months of age. These dogs had behavioural abnormalities, gait and visual deficits and became progressively demented. All dogs examined had common ancestors. Light microscopic examination of tissues demonstrated extensive accumulation of granular, sudan black-staining autofluorescent material in the cytoplasm of neurones, retinal ganglion cells and some visceral cells. At ultrastructural examination inclusions of variable morphology were observed.

Key words

Canine ceroid-lipofuscinosis Animal model 

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References

  1. 1.
    Appleby EC, Longstaffe JA, Bell FR (1982) Ceroid lipofuscinosis in two Saluki dogs. J Comp Pathol 92:375–380Google Scholar
  2. 2.
    Cho D-Y, Leipold HW, Rudolph R (1986) Neuronal ceroidosis (ceroid lipofuscinosis) in a blue heeler dog. Acta Neuropathol (Berl) 69:161–164Google Scholar
  3. 3.
    Goebel HH, Dahme E (1985) Retinal ultrastructure of neuronal ceroid-lipofuscinosis in the Dalmation dog. Acta Neuropathol (Berl) 68:224–229Google Scholar
  4. 4.
    Goebel HH, Koppang N, Zeman W (1979) Ultrastructure of the retina in canine neuronal ceroid lipofuscinosis. Ophthalmic Res 11:65–72Google Scholar
  5. 5.
    Koppang N (1970) Neuronal ceroid-lipofuscinosis in English Setters. J Small Anim Pract 10:639–644Google Scholar
  6. 6.
    Koppang N (1982) Ceroid-lipofuscinosis in the English Setter. A review. In: Armstrong D, Koppang N, Rider JA (eds) Ceroid-lipofuscinosis (Batten's disease). Elsevier Biomedical Press, Amsterdam, pp 201–217Google Scholar
  7. 7.
    Neville H, Armstrong D, Wilson B, Koppang N, Wehling C (1980) Studies on the retina and the pigment epithelium in hereditary canine ceroid lipofuscinosis. III. Morphologic abnormalities in retinal neurons and retinal pigmented epithelial cells. Invest Ophthalmol Vis Sci 19:75–86Google Scholar
  8. 8.
    Rac R, Giesecke PR (1975) Lysosomal storage disease in chihuahuas. Aust Vet J 51:403–404Google Scholar
  9. 9.
    Wolfe LS, Ivy GO, Witkop CJ (1987) Dolichols, lysosomal membrane turnover and relationships to the accumulation of ceroid and lipofuscin in inherited diseases, Alzheimer's disease and aging. Chem Scr 27:79–84Google Scholar
  10. 10.
    Zeman W (1976) The neuronal ceroid-lipofuscinoses. In: Zimmerman HM (ed) Progress in neuropathology, vol 3. Grune & Stratton, New York, pp 203–223Google Scholar

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • R. M. Taylor
    • 1
  • B. R. H. Farrow
    • 1
  1. 1.Department of Veterinary AnatomyUniversity of SydneyAustralia

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