Acta Neuropathologica

, Volume 75, Issue 6, pp 627–631 | Cite as

Ceroid-lipofuscinosis in Border Collie dogs

  • R. M. Taylor
  • B. R. H. Farrow
Regular Papers


Five Border Collie dogs with ceroid-lipofuscinosis developed progressive neurological disease between 18 and 22 months of age. These dogs had behavioural abnormalities, gait and visual deficits and became progressively demented. All dogs examined had common ancestors. Light microscopic examination of tissues demonstrated extensive accumulation of granular, sudan black-staining autofluorescent material in the cytoplasm of neurones, retinal ganglion cells and some visceral cells. At ultrastructural examination inclusions of variable morphology were observed.

Key words

Canine ceroid-lipofuscinosis Animal model 


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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • R. M. Taylor
    • 1
  • B. R. H. Farrow
    • 1
  1. 1.Department of Veterinary AnatomyUniversity of SydneyAustralia

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