Cancer Chemotherapy and Pharmacology

, Volume 25, Issue 6, pp 389–394 | Cite as

Platinum distribution inintraperitoneal tumors afterintraperitoneal cisplatin treatment

  • Gerrit Los
  • Peter H. A. Mutsaers
  • Willem J. M. Lenglet
  • Glenn S. Baldew
  • J. Gordon McVie
Original Articles Platinum Distribution, Cisplatin, Intraperitoneal

Summary

The spatial distribution of platinum (Pt) in the kidney was studied by an autoradiographic technique, in which cisplatin (CDDP) was replaced by195mPt-labeled CDDP, and by proton-induced X-ray emission (PIXE). Although both studies demonstrated comparable spatial distribution patterns, PIXE had the advantage that Pt concentrations could be determined quantitatively, in contrast to the relative information obtained by the autoradiographic technique. Using PIXE, the distribution of Pt in i.p. tumors was studied after i.p. administration of CDDP. The highest Pt concentrations were always found on the periphery of tumors, indicating that the periphery was exposed to a higher drug concentration than the center. Dose was correlated to the concentration of CDDP at both the center and the periphery (r=0.99).The Pt concentration in the periphery was usually higher by a factor of 2–3 after i.p. administration than after i.v. treatment, whereas in the center of the tumor no concentration difference could be detected. The penetration depth of CDDP lay between 1 and 2 mm and was calculated from the differences in Pt concentration after i.p. and i.v. treatment. This indicates that the effective advantage of i.p. chemotherapy with CDDP in cases of cancers limited to the peritoneal cavity is accentuated at the periphery of the tumor.

Keywords

Platinum Spatial Distribution Cancer Research Distribution Pattern Drug Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • Gerrit Los
    • 1
  • Peter H. A. Mutsaers
    • 2
  • Willem J. M. Lenglet
    • 3
  • Glenn S. Baldew
    • 4
  • J. Gordon McVie
    • 1
  1. 1.Department of Experimental ChemotherapyThe Netherlands Cancer InstituteAmsterdamThe Netherlands
  2. 2.Cyclotron LaboratoryEindhoven University of TechnologyEindhovenThe Netherlands
  3. 3.Department of PhysicsThe Free UniversityAmsterdamThe Netherlands
  4. 4.Department of RadiochemistryIRI, Interfaculty Reactor InstituteDelftThe Netherlands

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