Cancer Chemotherapy and Pharmacology

, Volume 36, Issue 1, pp 83–86

Distribution of cisplatin in perilymph and cerebrospinal fluid after intravenous administration in the guinea pig

  • Goran Laurell
  • Anita Andersson
  • Berit Engström
  • Hans Ehrsson
Short Communication Pharmacokinetics, Blood-CSF Barrier, Blood-Perilymph Barrier

Abstract

The concentration of free cisplatin was followed in plasma, scala tympani perilymph and cerebrospinal fluid (CSF) after an intravenous injection (12.5 mg/kg) in guinea pigs. Liquid chromatography with postcolumn derivatization was used for quantitative determination of the drug. The distribution of cisplatin to CSF was fast; at 10 min after drug administration the concentration was 7 μg/ml and the CSF:plasma ratio was 0.37. Cisplatin seems to distribute more slowly to the perilymphatic compartment. The highest concentration measured was 4 μg/ml at 20 min after the injection, and the perilymph:plasma ratio was 0.40 at that time. The concentration-time curves generated for cisplatin in perilymph and CSF were similar. No accumulation in the perilymphatic compartment or CSF was observed.

Key words

Pharmacokinetics Blood-CSF barrier Blood-perilymph barrier 

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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • Goran Laurell
    • 1
  • Anita Andersson
    • 3
  • Berit Engström
    • 1
    • 2
  • Hans Ehrsson
    • 3
  1. 1.Department of OtolaryngologyKarolinska HospitalStockholmSweden
  2. 2.Department of Physiology IIKarolinska InstituteStockholmSweden
  3. 3.Karolinska PharmacyStockholmSweden

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