Acta Neuropathologica

, Volume 36, Issue 3, pp 221–233 | Cite as

Presenile dementia with Alzheimer-, Pick- and Lewy-body changes

  • Kenji Kosaka
  • Shinsaku Oyanagi
  • Masaaki Matsushita
  • Akira Hori
  • Shoji Iwase
Original Investigations


An autopsy case of unclassifiable presenile dementia is reported. The outstanding pathological findings were as follows;
  1. 1.

    presence of senile plaques, neurofibrillary changes, Pick bodies, Hirano bodies, granulovacuolar degeneration of neurons, etc.

  2. 2.

    numerous Lewy bodies in the brain stem and diencephalon,

  3. 3.

    peculiar swollen neurons with intracytoplasmic, eosinophilic and argentophilic inclusions (“Lewy-like-bodies”) in the cerebral cortices.


Detailed study of the last mentioned inclusions indicates that they are almost identical to Lewy bodies, though there are some minor differences, in histochemical and electronmicroscopic findings.

Nosologically, this case may represent either a combination of Alzheimer's disease, Pick's disease and idiopathic Parkinsonism with “Lewy-like-bodies” in the cerebral cortices, or a single disease.

As far as we know, no similar case been reported.

Key words

Lewy body Idiopathic Parkinsonism Alzheimer's disease Pick's disease Unclassifiable presenile dementia 


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Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • Kenji Kosaka
    • 1
  • Shinsaku Oyanagi
    • 1
  • Masaaki Matsushita
    • 1
  • Akira Hori
    • 1
  • Shoji Iwase
    • 2
  1. 1.Division of NeuropathologyPsychiatric Research Institute of TokyoTokyoJapan
  2. 2.Moriyamaso HospitalNagoyaJapan

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