Acta Neuropathologica

, Volume 25, Issue 3, pp 228–236 | Cite as

Origin of macrophages in traumatic lesions and Wallerian degeneration in peripheral nerves

  • Aasmund Berner
  • Ansgar Torvik
  • Anna Elisabeth Stenwig
Original Investigations


The origin of the macrophages in peripheral nerves was investigated in newborn rabbits after labelling the blood monocytes with intravenous carbon suspensions.

Carbon labelled lipid macrophages were observed at the site of trauma in the nerves but not in areas of Wallerian degeneration. It is suggested that in Wallerian degeneration, resorption of degenerate tissue is performed by endogenous cells only, while in traumatic lesions part of the phagocytosis is performed by migrated monocytes. The early increase in vascular permeability in traumatic lesions may be a prerequisite for the attraction of the monocytes.

Key words

Wallerian Degeneration Peripheral Nerves Macrophages Monocytes 


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Copyright information

© Springer-Verlag 1973

Authors and Affiliations

  • Aasmund Berner
    • 1
  • Ansgar Torvik
    • 1
  • Anna Elisabeth Stenwig
    • 1
  1. 1.Laboratory of NeuropathologyUllevål HospitalOsloNorway

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