Acta Neuropathologica

, Volume 36, Issue 1, pp 1–8

Experimental cerebral ischemia in Mongolian gerbils

IV. Behaviour of biogenic amines
  • B. B. Mršulja
  • B. J. Mršulja
  • M. Spatz
  • U. Ito
  • J. T. WalkerJr.
  • I. Klatzo
Original Investigations

Summary

Behaviour of biogenic amines was studied in the brains of Mongolian gerbils subjected to unilateral occlusion of the common carotid artery. Assays on the hemispheres ipsilateral to occlusion revealed in symptom-positive animals a progressive decrease in norepinephrine and dopamine, and an increase in serotonin throughout the duration of an ischemic insult. In post-ischemic periods following the release of the clip, changes in biogenic amine levels generally conformed to the principles of a previously described “maturation” phenomenon, with delayed reactions occurring after the shorter ischemic insults.

Key words

Cerebral ischemia Biogenic amines Mongolian gerbils 

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Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • B. B. Mršulja
    • 1
  • B. J. Mršulja
    • 1
  • M. Spatz
    • 1
  • U. Ito
    • 1
  • J. T. WalkerJr.
    • 1
  • I. Klatzo
    • 1
  1. 1.Laboratory of Neuropathology and Neuroanatomical Sciences National Institute of Neurological and Communicative Disorders and Stroke National Institutes of HealthBethesdaUSA
  2. 2.Institute of Biochemistry, School of MedicineUniversity of BelgradeBelgradeYugoslavia
  3. 3.Institute for Biological ResearchBelgradeYugoslavia
  4. 4.Department of NeurosurgeryTokyo Medical and Dental UniversityTokyoJapan

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