Acta Neuropathologica

, Volume 46, Issue 1–2, pp 33–38 | Cite as

Ultrastructural and electrophysiological features of meningioma whorls in tissue culture

  • P. McL Black
  • Th. Liszczak
  • P. L. Kornblith
Original Works
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Accepted:

Summary

Cultured cells derived from a psammomatous meningioma were induced to from whorls in vitro by deprivation of nutrients. The ultrastructural features of desmosomes and junctional complexes were similar to sections from the surgical specimen; also prominent were 9–10 nm cytoplasmic filaments. Microelectrode recording of whorled cells showed a larger resting membrane potential than that of similar isolated meningioma cells in culture. Whorl formation seen in this tumor may be a result of relative nutritional deprivation and the need for metabolic cooperation among tumor cells.

Key words

Meningioma Brain neoplasms Tissue culture Cells, cultured Intercellular junctions 
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Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • P. McL Black
    • 1
  • Th. Liszczak
    • 1
  • P. L. Kornblith
    • 1
  1. 1.Neurosurgical ServiceMassachusetts General HospitalBostonUSA

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