Levels of benzene and other volatile aromatic compounds in the blood of non-smokers and smokers

  • H. Hajimiragha
  • U. Ewers
  • A. Brockhaus
  • A. Boettger
Article
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Summary

The concentrations of benzene, toluene, ethylbenzene, and o-, m- and p-xylene were measured in venous blood samples collected from 13 non-smokers and 14 cigarette smokers. The blood samples were analysed by a purge and trap technique followed by gas chromatography/mass spectrometry/computer analysis. The above-mentioned volatile organic compounds (VOC) could be detected in measurable amounts in all blood samples. This finding seems to reflect the ubiquitous exposure of humans to these agents in the urban environment, in non-smokers as well as in smokers. Smokers were found to have significantly higher blood concentrations of benzene (median 547 ng/l) and toluene (median 2201 ng/l) than non-smokers (median 190 ng/l and 1141 ng/l, respectively). The concentrations of ethylbenzene and xylenes also tended to be higher in smokers when compared to non-smokers. The different concentrations of these compounds in the blood of non-smokers appear to reflect the common concentration pattern found in outdoor urban air as well as in indoor air and also seem to be influenced by the different blood/air partition coefficients of these compounds. The results indicate that smoking is associated with a significant additional exposure to VOC, in particular to benzene and toluene.

Key words

Benzene Toluene Volatile organic compounds 
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References

  1. Angerer J (1979) Occupational chronic exposure to organic solvents. VII. Metabolism of toluene in man. Int Arch Occup Environ Health 43:63–67PubMedCrossRefGoogle Scholar
  2. Antoine SR, DeLeon IR, O'Dell-Smith RM (1986), Environmentally significant volatile organic pollutants in human blood. Bull Environ Contam Toxicol 36:364–371PubMedCrossRefGoogle Scholar
  3. Apostoli P, Brugnone F, Perbellini L (1982) Biomonitoring of occupational toluene exposure. Int Arch Occup Environ Health 50:153–159PubMedCrossRefGoogle Scholar
  4. Berlin M (1985) Low level benzene exposure in Sweden: effect on blood elements and body burden of benzene. Am J Ind Med 7:365–373PubMedCrossRefGoogle Scholar
  5. Berlin M, Gage JC, Gullberg B, Hom S, Knutsson P, Eng C, Tunek A (1980) Breath concentration as an index of the health risk from benzene. Scan J Work Environ Health 6:104–111Google Scholar
  6. Braier L, Levy A, Dror K, Pardo A (1981) Benzene in blood and phenol in urine in monitoring benzene exposure in industry. Am J Ind Med 2:119–123PubMedCrossRefGoogle Scholar
  7. Bruckmann P, Beier R, Krautscheid S (1983) Immissionsmessungen von Kohlenwasserstoffen in den Belastungsgebieten Rhein-Ruhr. Staub — Reinhalt Luft 43:404–410Google Scholar
  8. Bruckmann P, Kersten W, Funke W, Balfanz E, König J, Theisen J, Ball M, Päpke X (1988) The occurrence of chlorinated and other organic trace compounds in urban air. Chemosphere 12:2363–2380CrossRefGoogle Scholar
  9. Elmenhorst H, Schultz CH (1968) Flüchtige Inhaltsstoffe des Tabakrauches. Beiträge zur Tabakforschung 4:90–123Google Scholar
  10. Fiscrova-Bergerova V, Diaz ML (1986) Determination and prediction of tissue-gas partition coefficients. Int Arch Occup Environ Health 58:75–87CrossRefGoogle Scholar
  11. Fishbein L (1988a) Benzene: uses, occurrence and exposure. In: Fishbein L, O'Neill IK (eds) Environmental carcinogens — methods of analysis and exposure measurement, vol 10 — Benzene and alkylated benzenes. IARC Scientific Publications No. 85, pp 67–96. International Agency for Research on Cancer, LyonGoogle Scholar
  12. Fishbein L (1988b) Toluene: uses, occurrence and exposure. In: Fishbein L, O'Neill IK (eds) Environmental carcinogens — methods of analysis and exposure measurement, vol 10 — Benzene and alkylated benzenes. IARC Scientific Publications No. 85, pp 97–108. International Agency for Research on Cancer, LyonGoogle Scholar
  13. Fishbein L (1988c) Xylenes: uses, occurrence and exposure. In: Fishbein L, O'Neill IK (eds) Environmental carcinogens — methods of analysis and exposure measurement, vol 10 — Benzene and alkylated benzenes. IARC Scientific Publications No. 85, pp 109–120. International Agency for Research on Cancer, LyonGoogle Scholar
  14. Hartwell TD, Pellizzari ED, Perritt RL, Whitmore RW, Zelon HS, Sheldon LS, Sparacino CM (1987) Results from the total exposure assessment methodology (TEAM) study in selected communities in Northern and Southern California. Atmos Environ 21:1995–2004CrossRefGoogle Scholar
  15. IARC (International Agency for Research on Cancer) (1986) Tobacco smoking. IARC Monographs on the evaluation of the carcinogenic risk of chemicals to humans, vol. 38. IARC, LyonGoogle Scholar
  16. Krause C, Mailahn W, Nagel R, Schulz C, Seifert B, Ullrich D (1987) Occurrence of volatile organic compounds in the air of 500 homes in the Federal Republic of Germany. Indoor air '87. Proc 4th Int Conf Indoor Air Quality and Climate, Berlin (West), 17–31 August 1987, vol 1, pp 102–106Google Scholar
  17. Lauwerys RR (1983) Industrial chemical exposure: guidelines for biological monitoring. Biomedical Publications, Davis, CAGoogle Scholar
  18. LIS (Landesanstalt für Immissionsschutz des Landes Nordrhein-Westfalen) (1988) Die Immissionsbelastung durch Benzol in Nordrhein-Westfalen. LIS-Berichte Nr. 82Google Scholar
  19. Norpoth K, Stücker W, Krewet E, Müller G (1988) Biomonitoring of benzene exposure by trace analyses of phenylguanine. Int Arch Occup Environ Health 60:163–168PubMedCrossRefGoogle Scholar
  20. Perbellini L, Faccini GB, Pasini F, Cazzoli F, Pistoia S, Rosellini R, Valsecchi M, Brugnone F (1988) Environmental and occupational exposure to benzene by analysis of breath and blood. Br J Ind Med 45:345–352PubMedGoogle Scholar
  21. Sato A (1988) Toxicokinetics of benzene, toluene and xylenes. In: Fishbein L, O'Neill IK (eds) Environmental carcinogens — methods of analysis and exposure measurement, vol 10 — Benzene and alkylated benzenes. IARC Scientific Publications No. 85, pp 47–64. International Agency for Research on Cancer, Lyon (France)Google Scholar
  22. Sato A, Nakajima T (1979) Partition coefficients of some hydrocarbons and ketones in water, blood and oil. Br J Ind Med 36:231–234PubMedGoogle Scholar
  23. Seifert B, Ulrich D, Mailahn W, Nagel R (1986) Flüchtige organische Verbindungen in der Innenraumluft. Bundesgesundheitsblatt 29:417–424Google Scholar
  24. Sherwood RJ (1972) Benzene: The interpretation of monitoring results. Ann Occup Hyg 15:409–421PubMedCrossRefGoogle Scholar
  25. Sherwood R (1976) Ostwald solubility coefficients of some industrial important substances. Br J Ind Med 33:106–107PubMedGoogle Scholar
  26. Szadkowski D, Pett R, Angerer J, Manz A, Lehnert G (1973) Chronische Lösungsmittelbelastung am Arbeitsplatz. II. Schadstoffspiegel im Blut und Metabolitenelimination im Harn und ihre Bedeutung als Überwachungskriterien bei toluolexponierten Tiefdruckern. Int Arch Arbeitsmed 31:265–276PubMedCrossRefGoogle Scholar
  27. Wallace LA, Pellizzari ED (1986) Personal air exposure and breath concentrations of benzene and other volatile hydrocarbons for smokers and non-smokers. Toxicol Lett 35:113–116CrossRefGoogle Scholar
  28. Wallace LA, Pellizzari ED, Hartwell TD, Sparacino CM, Sheldon LS, Zelon H (1985) Personal exposures, indoor-outdoor relationships, and breath levels of toxic air pollutants measured for 355 persons in New Jersey. Atmos Environ 19:1651–1661CrossRefGoogle Scholar
  29. Wallace L, Pellizzari E, Hartwell T, Zelon H, Sparacino C, Perritt R, Whitmore R (1986) Concentrations of 20 volatile organic compounds in the air and drinking water of 350 residents of New Jersey compared with concentrations in their exhaled breath. J Occup Med 28:603–60PubMedCrossRefGoogle Scholar
  30. Wallace L, Pellizzari E, Leaderer B, Zelon H, Sheldon L (1987) Emissions of volatile organic compounds from building materials and consumer products. Atmos Environ 21:385–393CrossRefGoogle Scholar
  31. WHO (1985) Toluene. Environmental health criteria 52. World Health Organization, GenevaGoogle Scholar
  32. WHO-Euro (= WHO Regional Office for Europe) (1987) Air quality guidelines for Europe. WHO Regional Publications, European Series No. 23Google Scholar

Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • H. Hajimiragha
    • 1
  • U. Ewers
    • 1
  • A. Brockhaus
    • 1
  • A. Boettger
    • 1
  1. 1.Medical Institute of Environmental Hygiene at the University of DüsseldorfDüsseldorf 1Germany

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