Breast Cancer Research and Treatment

, Volume 33, Issue 2, pp 163–170 | Cite as

Allium vegetable consumption, garlic supplement intake, and female breast carcinoma incidence

  • Elisabeth Dorant
  • Piet A. van den Brandt
  • R. Alexandra Goldbohm


The risk of female breast carcinoma in relation to onion and leek consumption and the use of garlic supplements was evaluated in the Netherlands Cohort Study on diet and cancer. Onions, leeks, and garlic contain specific compounds which might act as antimutagens. Animal experiments also suggest a possible role for these compounds in inhibition of mammary carcinogenesis.

The Netherlands Cohort Study was started in 1986 among 120,852 Dutch men and women, aged 55-69 years, with collecting information on usual diet and important lifestyle characteristics. After 3.3 years of follow-up, 469 incident female breast carcinoma cases and 1713 female members of a randomly sampled control subcohort were available for analysis. Intake of onions or leeks was not associated with breast carcinoma risk after controlling for dietary and nondietary risk factors: the rate ratios in the highest intake categories were 0.95 (95% confidence interval 0.61–1.47) and 1.08 (95% confidence interval 0.79–1.48), respectively, compared with the lowest intake categories. The tests for trend in the rate ratios were neither significant. Garlic supplement use was also not associated with breast carcinoma incidence (rate ratio = 0.87, 95% confidence interval 0.58–1.31).

In conclusion, we found no association between the consumption of onions or leeks, or garlic supplement use, and the incidence of female breast carcinoma.

Key words

Allium vegetables breast carcinoma cohort study diet garlic supplements 


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  1. 1.
    De Winter GA, Coebergh JWW, Van Leeuwen FE, Schouten L (eds): Incidence of cancer in the Netherlands, 1989. First report of The Netherlands cancer registry. Coordinating Council of Comprehensive Cancer Registries, Utrecht, 1993Google Scholar
  2. 2.
    Steinmetz K, Potter JD: Vegetables, fruit, and cancer. I. Epidemiology. Cancer Causes Control 2: 325–357, 1991Google Scholar
  3. 3.
    Block G, Patterson B, Subar A: Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence. Nutr Cancer 18: 1–29, 1992Google Scholar
  4. 4.
    Howe G, Hirohata T, Hislop G, Iscovich JM, Yuan JM, Katsouyanni K, Lubin F, Marubini E, Modan B, Rohan T, Tonioli P, Shunzhang Y: Dietary factors and risk of breast cancer: combined analysis of 12 case-control studies. J Natl Cancer Inst 82: 561–569, 1990Google Scholar
  5. 5.
    Wattenberg LW: Chemoprevention of cancer. Cancer Res 45: 1–8, 1985Google Scholar
  6. 6.
    Ames BN: Dietary carcinogens and anticarcinogens. Science 221: 1256–1264, 1983Google Scholar
  7. 7.
    Steinmetz K, Potter JD: Vegetables, fruit, and cancer. II. Mechanisms. Cancer Causes Control 2: 427–442, 1991Google Scholar
  8. 8.
    Newmark HL: Plant phenolics as inhibitors of mutational and precarcinogenic events. Can J Physiol Pharmacol 65: 461–466, 1987Google Scholar
  9. 9.
    Herrmann K: Flavonols and flavones in food plants: a review. J Food Technol 11: 433–448, 1976Google Scholar
  10. 10.
    Bilyk A, Sapers GM: Distribution of quercetin and kaempferol in lettuce, kale, chive, garlic chive, leek, horseradish, red radish, and red cabbage tissues. J Agric Food Chem 33: 226–228, 1985Google Scholar
  11. 11.
    Hertog MGL, Hollman CH, Katan MB: Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in The Netherlands. J Agric Food Chem 40: 2379–2383, 1992Google Scholar
  12. 12.
    Coles B, Ketterer B: The role of glutathione and glutathione transferases in chemical carcinogenesis. Crit Rev Biochem Mol Biol 25: 47–70, 1990Google Scholar
  13. 13.
    Whitaker JR: Development of flavor, odor, and pungency in onion and garlic. Adv Food Res 22: 73–133, 1976Google Scholar
  14. 14.
    Block E: The organosulfur chemistry of the genus Allium -Implications for the organic chemistry of sulfur. Angew Chem Int Ed Engl 31: 1135–1178, 1992Google Scholar
  15. 15.
    Dorant E, Van den Brandt PA, Goldbohm RA, Hermus RJJ, Sturmans F: Garlic and its significance for the prevention of cancer in humans: a critical view. Br J Cancer 67: 424–429, 1993Google Scholar
  16. 16.
    Verma AK, Johnson JA, Gould MN, Tanner MA: Inhibition of 7,12-dimethylbenz[a]anthracene- and N-nitrosomethylurea-induced rat mammary cancer by dietary flavonol quercetin. Cancer Res 48: 5754–5758, 1998Google Scholar
  17. 17.
    Ip C, Ganther HE: Combination of blocking agents and suppressing agents in cancer prevention. Carcinogenesis 12: 365–367, 1991Google Scholar
  18. 18.
    Lawson LD, Wang ZYJ, Hughes BG: Identification and HPLC quantification of the sulfides and dialk(en)yl thiosulfinates in commercial garlic products. Planta Med 57: 363–370, 1991Google Scholar
  19. 19.
    Dorant E, Van den Brandt PA, Hamstra AM, Feenstra MH, Goldbohm RA, Hermus RJJ, Sturmans F: The use of vitamins, minerals and other dietary supplements in The Netherlands. Int J Vit Nutr Res 63: 4–10, 1993Google Scholar
  20. 20.
    Liu J, Lin RI, Milner JA: Inhibition of 7,12-dimethylbenz[a]anthracene-induced mammary tumors and DNA adducts by garlic powder. Carcinogenesis 13: 1847–1851, 1992Google Scholar
  21. 21.
    Amagase H, Milner JA: Impact of various sources of garlic and their constituents on 7,12-dimethylbenz[a]anthracene binding to mammary cell DNA. Carcinogenesis 14: 1627–1631, 1993Google Scholar
  22. 22.
    Katsouyanni K, Trichopoulos D, Boyle P, Xirouchaki E, Trichopoulou A, Lisseos B, Vasilaros S, MacMahon B: Diet and breast cancer: a case-control study in Greece. Int J Cancer 38: 815–820, 1986Google Scholar
  23. 23.
    Levi F, La Vecchia C, Gulie C, Negri E: Dietary factors and breast cancer risk in Vaud, Switzerland. Nutr Cancer 19: 327–335, 1993Google Scholar
  24. 24.
    Van den Brandt PA, Goldbohm RA, Van 't Veer P, Volovics A, Hermus RJJ, Sturmans F: A large-scale prospective cohort study on diet and cancer in The Netherlands. J Clin Epidemiol 43: 285–295, 1990Google Scholar
  25. 25.
    Van den Brandt PA, Schouten LJ, Goldbohm RA, Dorant E, Hunen PMH: Development of a record linkage protocol for use in the Dutch Cancer Registry for epidemiological research. Int J Epidemiol 19: 553–558, 1990Google Scholar
  26. 26.
    Van den Brandt PA, Van 't Veer P, Goldbohm RA, Dorant E, Volovics A, Hermus RJJ, Sturmans F: A prospective cohort study on dietary fat and the risk of postmenopausal breast cancer. Cancer Res 53: 75–82, 1993Google Scholar
  27. 27.
    Goldbohm RA, Van den Brandt PA, Brants HAM, Van 't Veer P, Al M, Sturmans F, Hermus RJJ: Validation of a dietary questionnaire used in a large-scale prospective cohort study on diet and cancer. Eur J Clin Nutr 48: 253–265, 1994Google Scholar
  28. 28.
    Dorant E, Van den Brandt PA, Goldbohm RA, Hermus RJJ, Sturmans F: Agreement between interview data and a self-administered questionnaire on dietary supplement use. Eur J Clin Nutr 48: 180–188, 1994Google Scholar
  29. 29.
    Stichting NEVO: NEVO table; Dutch food composition table 1986–1987. The Hague, Netherlands: Voorlichtingsbureau voor de Voeding, 1986Google Scholar
  30. 30.
    Gugler R, Leschik M, Dengler HJ: Disposition of quercetin in man after single oral and intravenous doses. Eur J Clin Pharmacol 9: 229–234, 1975Google Scholar
  31. 31.
    Clark WG, MacKay EM: The absorption and excretion of rutin and related flavonoid substances. JAMA 143: 1411–1415, 1950Google Scholar
  32. 32.
    Jones DP, Coates RJ, Flagg EW, Eley JW, Block G, Greenberg RS, Gunter EW, Jackson B: Glutathione in foods listed in the National Cancer Institute's Health Habits and History Food Frequency Questionnaire. Nutr Cancer 17: 57–75, 1992Google Scholar

Copyright information

© Kluwer Academic Publishers 1995

Authors and Affiliations

  • Elisabeth Dorant
    • 1
  • Piet A. van den Brandt
    • 1
  • R. Alexandra Goldbohm
    • 1
    • 2
  1. 1.Department of EpidemiologyUniversity of LimburgMaastrichtThe Netherlands
  2. 2.Department of NutritionTNO-Toxicology and Nutrition InstituteZeistThe Netherlands

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