Breast Cancer Research and Treatment

, Volume 34, Issue 2, pp 129–137

Obesity and subcutaneous fat patterning in relation to survival of postmenopausal breast cancer patients participating in the DOM-project

  • Isolde den Tonkelaar
  • Frits de Waard
  • Jacob C. Seidell
  • Jacques Fracheboud
Report

DOI: 10.1007/BF00665785

Cite this article as:
den Tonkelaar, I., de Waard, F., Seidell, J.C. et al. Breast Cancer Res Tr (1995) 34: 129. doi:10.1007/BF00665785

Summary

The effect of obesity and fat distribution on survival of breast cancer patients was studied prospectively in 241 women with a natural menopause who participated in a breast cancer screening project, the DOM-project in Utrecht, The Netherlands. Mean follow-up time was 9.1 years and endpoint of interest was death from breast cancer. Fat distribution was assessed by contrasting groups of subscapular and triceps skinfold thickness.

No significant differences in survival time between more obese (Quetelet's index ≥ 26 kg/m2) and leaner (Quetelet's index < 26 kg/m2) patients or between patients with central fat distribution and patients with peripheral fat distribution were observed. Analyses were stratified by axillary node status, estrogen receptor status, and way of detection (by first screening or afterwards). Results of the stratified analyses were suggestive of a modifying effect of these factors.

The absence of an association between obesity and survival time might be explained by two counteracting mechanisms. On the one hand obesity might be related to impaired survival, due to a tumor growth promoting effect of extra-ovarian estrogens. On the other hand obesity might be related to improved survival in a screened population, because obese patients profit more from screening by earlier detection of tumors than leaner counterparts.

Key words

breast cancer fat distribution obesity prognosis postmenopausal survival 

Copyright information

© Kluwer Academic Publishers 1995

Authors and Affiliations

  • Isolde den Tonkelaar
    • 1
  • Frits de Waard
    • 1
  • Jacob C. Seidell
    • 2
  • Jacques Fracheboud
    • 1
  1. 1.Department of EpidemiologyUniversity of UtrechtUtrechtThe Netherlands
  2. 2.Department of Chronic Disease and Environmental EpidemiologyNational Institute of Public Health and Environmental ProtectionBilthovenThe Netherlands

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