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Breast Cancer Research and Treatment

, Volume 25, Issue 1, pp 11–19 | Cite as

Selenium and the risk of postmenopausal breast cancer in the DOM cohort

  • P. A. H. van Noord
  • M. J. Maas
  • I. van der Tweel
  • C. Collette
Report

Summary

Selenium has been claimed to have chemo-preventive properties. However, data showing that in humans selenium levels are already decreased prior to diagnosis of breast cancer were not available. Such information is mandatory before oral selenium supplementation in the primary prevention of (breast) cancer in humans is acceptable. This question of a ‘preventive-potential’ of selenium was evaluated in a case-control study nested in a cohort, because this design allows determination of the time-order of preceding selenium levels and subsequent cancer risk.

The cohort consisted of 5577 women aged 55–70 years from the DOM project, a population based breast cancer screening program in the Netherlands. Instrumental Neutron Activation Analysis was used to measure the selenium content of toenail clippings. The 69 cases of breast cancer found during follow-up after screening represent ‘recent’ tumours since all women had a negative screening mammogram 3–5 years previously.

No decreased selenium levels, as measured in nail clippings from the big toes, could be detected in cases-to-be, either when compared to 4 age matched controls per case or when compared with a random control group drawn from the entire cohort. On the contrary, a tendency for slightly higher selenium levels among ‘future’ cancer cases was observed.

As to the sensitivity of detecting differences in selenium by nail clippings, lower selenium could be detected in nails of current smokers. The smoking-related decrease in nail selenium level was of the same order as the differences between breast cancer cases and controls, but was independent of the breast cancer risk.

Results are similar to a comparable study on premenopausal breast cancer and argue against a preventive role for selenium on breast cancer risk.

Key words

selenium breast cancer risk epidemiology cohort study postmenopausal breast cancer nail 

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References

  1. 1.
    Clark LC: The epidemiology of selenium and cancer. Selenium and carcinogenesis. Fed Proc 44: 2584–2589, 1985Google Scholar
  2. 2.
    Thompson HJ, Herbst EJ, Meeker LD: Chemoprevention of mammary carcinogenesis: a comparative review of the efficacy of a polyamine antimetabolite, retinoids, and selenium. JNCI 77: 585–598, 1986Google Scholar
  3. 3.
    Ip C: Selenium inhibition of chemical carcinogenesis. Fed Proc 44: 2573–2578, 1985Google Scholar
  4. 4.
    Shamberger RJ, Rukovena E, Longfield AK, Tytko SA, Deodhar S, Willis CE: Antioxidants and cancer: selenium in the blood of normals and cancer patients. JNCI 50: 863–870, 1973Google Scholar
  5. 5.
    Rizk SL, Sky-Peck HH: Comparison between concentrations of trace elements in normal and neoplastic human breast tissue. Cancer Research 44: 54390–5394, 1984Google Scholar
  6. 6.
    Salonen JF, Alfthan G, Huttunen JK, Puska P: Association between selenium and the risk of cancer. Am J Epidemiol 120: 342–349, 1984Google Scholar
  7. 7.
    Willett WC, Plok BF, Morris JS, Stampfer MJ, Pressel S, Rosner B, Taylor JO: Prediagnostic selenium and risk of cancer. Lancet 1: 130–134, 1983Google Scholar
  8. 8.
    de Waard F, Baanders-van Halewijn EA, Huizinga J: The bimodal age distribution of patients with mammary cancer. Cancer 17: 141–151, 1964Google Scholar
  9. 9.
    van Noord PAH, Collette HJA, Maas MJ, de Waard F: Selenium levels in nails of pre-menopausal breast cancer patients assessed prediagnostically in a cohort-nested case-referent study among women screened in the DOM project. Int J Epidemiol 16: 2 (Suppl) 318–322, 1987Google Scholar
  10. 10.
    Hadjimarkos DM, Shearer TR: Selenium content of human nails: a new index for epidemiologic studies of dental caries. J Dent Res 52: 389, 1973Google Scholar
  11. 11.
    Morris JS, Stampfer MJ, Willett WC: Dietary selenium in humans: toenails as an indicator. Biol Trace Elem Res 5: 529–537, 1983Google Scholar
  12. 12.
    Hunter DJ, Morris JC, Chute CG, Kushner E, Colditz GA, Stampfer MJ, Speizer FE, Willett WC: Predictors of selenium concentration in nail tissue. Am J Epidemiol 132: 114–122, 1990Google Scholar
  13. 13.
    de Waard F, Collette HJA, Rombach JJ, Baanders-van Halewijn EA, Honig C: The DOM-project for the early detection of breast cancer, Utrecht, the Netherlands. J Chron Dis 1: 1–44, 1984Google Scholar
  14. 14.
    Wacholder S, Boivin JF: External comparisons with the case-cohort design. Am J Epidemiol 126: 1198–1209, 1987Google Scholar
  15. 15.
    Gail M, Williams R, Byar DP, Brown C: How many controls? J Chron Dis 29: 723–731, 1976Google Scholar
  16. 16.
    Longnecker MP, Taylor PR, Levander OA, Howe SM, Veillon S, McAdam PA, Patterson KY, Holden JM, Stampfer MJ, Morris SJ, Willett WC: Tissue selenium (Se) levels and indices of Se exposure in a seleniferous area. Fed Proc 46: 587–580, 1987Google Scholar
  17. 17.
    Swanson CA, Longnecker MP, Veillon C, Howe M, Levander OA, Taylor PR, Hardison N, Brown C, Stampfer MJ, Willett WC: Determinants of blood and toenail selenium (Se) concentration in South Dakota adults. Fed Poc 3: 779 abstr 3212, 1989Google Scholar
  18. 18.
    van Noord PAH: Selenium and human cancer risk; nail keratin as a tool in metabolic epidemiology. Thesis, Rijks Universiteit Utrecht, The Netherlands, 1992Google Scholar
  19. 19.
    Baron J: Cigarette smoking and age at natural menopause. In: Wald N, Baron J (eds) Smoking and Hormone-related Disorders. Oxford Univ Press, 1990, ch. 4.Google Scholar
  20. 20.
    Keloff GJ, Malone W, Boone ChW, Sigman CC, Fay JR: Progress in applied chemopreventive research. Semin Oncol 17: 438–455, 1990Google Scholar
  21. 21.
    Hulshof KFAM: Spoorzoeken in voedingsmiddelen. Voeding 46: 227–232, 1985Google Scholar
  22. 22.
    Sakurai H, Tsuchiya K: A tentative recommendation for the maximum daily intake of selenium. Environm Physiol Biochem 5: 107–118, 1975Google Scholar
  23. 23.
    Rose G: Sick individuals and sick populations. Int J Epidemiol 14: 32–38, 1985Google Scholar
  24. 24.
    Sundstrom H, Yrjanheikki E, Kauppila A: Serum selenium in patients with ovarian cancer during and after therapy. Carcinogenesis 6: 731–734, 1984Google Scholar
  25. 25.
    Miyamoto H, Araya Y, Ito M, Isobe H, Dosaka H, Shimizu T, Kishi F, Yamamoto I, Honma H, Kawakami Y: Serum selenium and vitamin E concentrations in families of lung cancer patients. Cancer 60: 1159–1162, 1987Google Scholar
  26. 26.
    Hunter DJ, Morris JS, Stampfer MJ, Colditz GA, Speizer FE, Willett WC: A prospective study of selenium status and breast cancer risk. JAMA 264: 1128–1131, 1990Google Scholar
  27. 27.
    Coates RJ, Weiss NS, Daling JR, Morris JS, Labbe RF: Serum levels of selenium and retinol and the subsequent risk of cancer. Am J Epidemiol 128: 15–23, 1988Google Scholar
  28. 28.
    Knekt P, Aromaa A, Maatela J, Alfthan G, Aaran RK, Hakama M, Hakulinen T, Peto R, Teppo L: Serum selenium and subsequent risk of cancer among Finnish men and women. JNCI 82: 864–868, 1990Google Scholar
  29. 29.
    Criqui MH, Bangdiwala S, Goodman DS: Selenium, retinolbinding protein, and uric acid associations with cancer mortality in a population based prospective case-control study. Ann Epidemiol 1: 385–393, 1991Google Scholar
  30. 30.
    Ringstad J, Jacobsen BK, Tretli S, Thomassen Y: Serum selenium concentration associated with risk of cancer. J Clin Pathol 41: 454–457, 1988Google Scholar
  31. 31.
    Meyer F, Verrault R: Erythrocyte selenium and breast cancer risk. Am J Epidemiol 125: 917–919, 1987Google Scholar

Copyright information

© Kluwer Academic Publishers 1993

Authors and Affiliations

  • P. A. H. van Noord
    • 1
  • M. J. Maas
    • 1
  • I. van der Tweel
    • 2
  • C. Collette
    • 1
  1. 1.Dept. of EpidemiologyRU UtrechtUtrechtThe Netherlands
  2. 2.Centre for BiostatisticsRijks Universiteit at UtrechtThe Netherlands

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