European Journal of Pediatrics

, Volume 146, Issue 1, pp 34–37

The importance of primary cytomegalovirus infection in childhood cancer

  • T. Furukawa
  • Y. Funamoto
  • S. Ishida
  • H. Kamiya
Original Investigations

DOI: 10.1007/BF00647279

Cite this article as:
Furukawa, T., Funamoto, Y., Ishida, S. et al. Eur J Pediatr (1987) 146: 34. doi:10.1007/BF00647279


Sixty-eight paediatric patients with malignant tumours or leukaemia were followed for signs of infection with human chtomegalovirus (HCMV) over 1 year. HCMV was isolated from 24 out of 68 patients at some point during the observation period; from urine in 14, from both urine and throat in 9 patients, and from throat alone in 1 patient. Previous antibody analysis indicated the presence of HCMV antibodies in 10 of the 24 virus-shedding patients, while 7 patients were seronegative and 7 undefined. Thus the incidence of reactivation appears to be higher than that of primary infection in these immunocompromised patients. The mean duration of virus shedding was 4.2 months in the primary infection group, 1.7 months in the reactivation group and 1.1 months in the undefined group. No difference in the incidence of HCMV-associated illness was observed between patients with leukaemia and those with malignant tumours. Clinical symptoms associated with HCMV infection (pneumonia (2), fever (6) and hepatitis (1)) were observed in all patients with primary infections and in only five patients with reactivated infection.

Key words

HCMV Primary infection Leukaemia 



human cytomegalovirus


cytopathic change


complement fixation


indirect fluorescent antibody assay

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • T. Furukawa
    • 1
  • Y. Funamoto
    • 1
  • S. Ishida
    • 1
  • H. Kamiya
    • 2
  1. 1.Department of MicrobiologyKanazawa Medical UniversityUchinada, IshikawaJapan
  2. 2.Department of PediatricsMie UniversityTsu, MieJapan

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