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European Journal of Clinical Pharmacology

, Volume 6, Issue 4, pp 211–216 | Cite as

Clinical evaluation of indoramin, a new antihypertensive agent

  • P. J. Lewis
  • C. F. George
  • C. T. Dollery
Originals

Summary

Indoramin, a new antihypertensive drug shown to have cardioinhibitory and alpha adrenoceptor blocking activity in animals, was administered to patients with benign essential hypertension. Single oral doses between 0.1 and 1.0 mg/kg produced dose dependent falls in diastolic arterial pressure without increasing the heart rate. The arterial pressure response to intravenous noradrenaline was diminished in patients taking indoramin, but the response to intravenous angiotensin II and heart rate responses to intravenous isoprenaline were unaltered. Double blind cross-over comparison of indoramin with placebo in 8 patients on continuous oral therapy at maximally tolerated doses, 60–150 mg daily, showed that indoramin significantly lowered diastolic arterial pressure, but that the falls were modest, 7.6 mm Hg lying, 7.1 mm Hg standing and 9.3 mm Hg after exercise. The dose limiting side effect was sedation.

Key words

Antihypertensive therapy alpha adrenoceptor blockade 

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References

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Copyright information

© Springer-Verlag 1973

Authors and Affiliations

  • P. J. Lewis
    • 1
  • C. F. George
    • 1
  • C. T. Dollery
    • 1
  1. 1.M.R.C. Clinical Pharmacology GroupRoyal Postgraduate Medical SchoolLondonEngland

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