European Journal of Clinical Pharmacology

, Volume 36, Issue 6, pp 617–619 | Cite as

Suppression of histamine-induced skin reactions by loratadine and cetirizine diHCl

  • K. Kontou-Fili
  • G. Paleologos
  • M. Herakleous
Originals

Summary

The skin reactivity to histamine was measured in 10 healthy and 10 atopic subjects after the ingestion of single doses of loratadine 10 mg, cetirizine diHCl 10 mg and placebo, in a double-blind cross-over randomized study.

The anti-H1 effect of cetirizine diHCl proved to be significantly more rapid, more pronounced and longer lasting than that of loratadine.

Key words

cetirizine loratadine histamine skin reactivity side-effects 

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References

  1. 1.
    Rihoux JP, Dupont P (1987) Comparative study of the peripheral and central effects of terfenadine and cetirizine diHCl. Ann Allergy 59: 235–238Google Scholar
  2. 2.
    Pechadre JC, Trolese JF, Bloom M, Dupont P, Rihoux JP (1987) Compared central and peripheral effects of terfenadine and cetirizine diHCl. Allergol Immunol Clin 2: 83Google Scholar
  3. 3.
    Snyder S, Snowman A (1987) Receptor effects of cetirizine. Ann Allergy 59 (Part II): 4–8Google Scholar
  4. 4.
    Fadel R, Herpin-Richard N, Rihoux JP, Henocq E (1987) Inhibitory effect of cetirizine diHCl on eosinophil migration in vivo. Clin Allergy 17: 373–379Google Scholar
  5. 5.
    Charlesworth EN, Kagey-Sobotka A, Norman PS, Lichtenstein LM (1988) Effects of cetirizine on mast cell mediator release and cellular traffic during the cutaneous late phase response. J Allergy Clin Immunol Allergy Abstracts 81: 212 (abstract 176)Google Scholar
  6. 6.
    Kreutzner W, Chapman RW, Gulbenkian A, Siegel MI (1987) Antiallergic activity of loratadine, a non-sedative antihistamine. Allergy 42: 57–63Google Scholar
  7. 7.
    Barnet A, Iorio LC, Kreutner W, Tozzi S, Ano HS, Gulbenkian A (1984) Evaluation of the CNS properties of SCH 29851, a potential non-sedative antihistamine. Agents Actions 14: 590–597Google Scholar
  8. 8.
    Sheldon GM, Lovell RG, Mathews KP (1967) A manual of clinical allergy. WB Saunders, Philadelphia, pp 56–59Google Scholar
  9. 8a.
    Harvey RP, Schocket AL (1980) The effect of H1- and H2-blockade on cutaneous histamine response in man. J Allergy Clin Immunol 65: 1356Google Scholar
  10. 9.
    Sidiropoulos J, Volonakis M, Kontou-Filik (1988) Inhibition of histamine-induced wheal and flare reactions by cetirizine diHCl and mequitazine both in healthy and atopic subjects. A comparative double-blind placebo-controlled study. Rev Clin Pharmacol Pharmacokinet 2: 110–119Google Scholar
  11. 10.
    Roman IJ, Kassem N, Gural RP, Herron J (1986) Suppression of histamine-induced wheal response by loratidine over 28 days in man. Ann Allergy 57: 253–256Google Scholar
  12. 11.
    Kassem N, Roman I, Gural RP, Dyer JG, Robillard N (1987) Effects of loratadine (SCH 29851) in suppression of histamine-induced skin wheals. Ann Allergy 60: 505–507Google Scholar
  13. 12.
    Poppa VT (1980) Effect of an H1-blocker, chlorpheniramine, on inhalation tests with histamine and allergen in allergic asthma. Chest 78: 442Google Scholar
  14. 13.
    Howarth PH, Holgate ST (1985) Astemizole, an H1-antagonist in allergic asthma. J Allergy Clin Immunol 75: (Part 2): 166 (Abst 248)Google Scholar
  15. 14.
    Tashkin DP, Brik A, Gong Jr H (1987) Cetirizine inhibition of histamine-induced bronchospasm. Ann Allergy 59 (Part 2): 49–52Google Scholar

Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • K. Kontou-Fili
    • 1
  • G. Paleologos
    • 1
  • M. Herakleous
    • 1
  1. 1.Section of AllergyLaikon General Hospital, GoudiAthensGreece

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