European Journal of Clinical Pharmacology

, Volume 33, Issue 4, pp 435–436 | Cite as

A clinically significant interaction between ciprofloxacin and theophylline

  • A. H. Thomson
  • G. D. Thomson
  • M. Hepburn
  • B. Whiting
Short Communications
Received:
Accepted:

Summary

We report a case of theophylline toxicity following the co-administration of ciprofloxacin. Total theophylline clearance fell from 2.3 l·h−1 to 0.8 l·h−1 when ciprofloxacin was added to the treatment regimen and returned to 2.1 l·h−1 after ciprofloxacin was discontinued.

Key words

theophylline ciprofloxacin drug interaction 
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References

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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • A. H. Thomson
    • 1
    • 2
  • G. D. Thomson
    • 2
  • M. Hepburn
    • 1
  • B. Whiting
    • 1
  1. 1.Department of Materia MedicaUniversity of GlasgowGlasgowUK
  2. 2.Department of PharmacyStobhill General HospitalGlasgowUK

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