The effects of 3 weeks of treatment with the beta-receptor blocking agent propranolol and a placebo on glucose tolerance, insulin secretion and peripheral insulin sensitivity have been evaluated in 7 normoglycaemic hypertensive patients by an oral glucose tolerance test and the insulin clamp technique.
Significant changes in systolic and diastolic blood pressure and heart rate were observed at the end of propranolol treatment, but there were no associated changes in glucose tolerance, insulin secretion or peripheral insulin sensitivity. No difference was observed in glucagon, growth hormone and free fatty acids between propranolol and placebo treatment.
The results support the view that the hypothetical pancreatic glucoreceptor, at least in non-acute studies, is not affected by beta blockade. In addition, there was no effect on tissue sensitivity to insulin.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Kaneto A, Miki E, Kosaka K (1975) Effect of beta1-and beta2-adrenoceptor stimulants infused intrapancreatically on glucagon and insulin secretion. Endocrinology 97: 335–346
Cerasi E, Luft R, Efendil S (1972) Effect of adrenergic blocking agents on insulin response to glucose infusion in man. Acta Endocrinol 69: 335–346
Moheler H, Bravo EL, Tarazi RC (1979) Glucose intolerance during chronic beta-adrenergic blockade in man. Clin Pharmacol Ther 25: 237–244
Groop L, Tottermann K, Horno H, Gordin A (1982) Influence of beta-blocking drugs on glucose metabolism in patients with non-insulin dependent diabetes mellitus. Acta Med Scand 211: 7–12
Groop L, Totterman KJ, Horno K, Gordin A (1983) Influence of beta-blocking drugs on glucose metabolism in hypertensive, non-diabetic patients. Acta Med Scand 213: 9–14
Hansson BJ, Hokfelt B (1976) Long-term treatment of moderate hypertension with penbutolol (Hoc 893 d)-Effect on glucose tolerance and insulin production. Eur J Clin Pharmacol 10: 157–160
Day JL, Simpson N, Metcalfe J, Page RL (1979) Metabolic consequences of atenolol and propranolol in treatment of essential hypertension. Br Med J 1: 77–80
Ekberg G, Hansen BG (1977) Glucose tolerance and insulin release in hypertensive patients treated with the cardioselective β-receptor blocking agent metoprolol. Acta Med Scand 202: 393–397
Groop L, Totterman KJ (1982) Propranolol does not inhibit solfonylurea-stimulated insulin secretion in patients with non-insulin dependent diabetes mellitus. Acta Endocrinol 100: 410–415
Hedstrand H, Aberg H (1974) Insulin response to intravenous glucose during long-term treatment with propranolol. Acta Med Scand 196: 39–45
Totterman KJ, Groop L, Groop PH, Kala R, Tolppanen EM, Fyhrquist F (1984) Effect of beta-blocking drugs on beta-cell function and insulin sensitivity in hypertensive non-diabetic patients. Eur J Clin Pharmacol 26: 13–17
Totterman KJ, Groop L (1982) No effect of propranolol and metoprolol on tolbutamide-stimulated insulin secretion in hypertensive diabetic and non-diabetic patients. Ann Clin Res 14: 190–193
Harurs HH, Gooren L, Spoelstrn AJG, Hesse C, Verschoor L (1978) Blockade of isoprenaline induced changes in plasma free fatty acids, immunoreactive insulin levels and plasma renin activity in healthy human subjects, by propranolol, pindolol, practolol, atenolol, metoprolol and acebutolol. Br J Clin Pharmacol 5: 19–26
Deibert DC, De Fronzo RA (1980) Epinephrine-induced insulin resistance in men. J Clin Invest 65: 717–721
WHO Expert Committee on Diabetes Mellitus (1980) Second report. World Health Organization Technical Report Series 648. Geneva, Switzerland
De Fronzo RA, Tobin JD, Andres R (1979) The glucose clamp technique. A method for the quantification of beta-cells sensitivity to glucose and of tissue sensitivity to insulin. Am J Physiol 237: E 214–223
Rizza RA, Mandarino LJ, Gerich JE (1981) Mechanisms of insulin resistance in man. Assessment using the insulin dose-response curve in conjunction with insulin-receptor binding. Am J Med 70: 169–176
Hugge ASG, Nixon DA (1957) Use of glucose oxidase, peroxidase and o-dianisidine in determination of blood and urinary glucose. Lancet 2: 368–370
Debuquois B, Aurbach GD (1971) Use of polyethylene glycol to separate free and antibody bound peptide hormones in radioimmunoassay. J Clin Endocrinol Metab 33: 732–738
Hartog M, Gaafar MA, Meissner B, Fraser R (1964) Immunoassay of serum growth hormone in acromegalic patients. Br Med J 2: 1229–1232
Nishino T, Kodaira T, Shin S, Imagawa K, Shina K, Kumahara Y, Yanaihara C, Yanaihara N (1981) Glucagon radioimmunoassay with use of antiserum to glucagon c-terminal fragment. Clin Chem 27: 1690–1697
Novak M (1965). Colorimetric ultramicro-method for the determination of free fatty acids. J Lipid Res 6: 431–433
Robertson RP, Porte DJ (1973) The glucose receptor. A defective mechanism in diabetes mellitus distinct from the beta-adrenergic receptor. J Clin Invest 52: 870–876
Simonson DC, Tamberlaine WV, De Fronzo RA, Sherwin RS (1985) Intensive insulin therapy reduces counterregulatory hormone responses to hypoglycemia in patients with type 1 diabetes. Ann Intern Med 103: 184–190
Yawata M, Fukase M (1968) Increased plasma levels of growth hormone during propranolol. J Clin Endocrinol Metab 28: 1079–1081
De Fronzo RA, Thobin D, Felber JP, Simonson DC, Thiebaund D, Jequier E, Dalay A (1984) Effect of beta- and alpha-adrenergic blockade on glucose-induced thermogenesis in man. J Clin Invest 73: 633–639
About this article
Cite this article
Ferrara, L.A., Capaldo, B., Rivellese, A. et al. Adrenergic system and carbohydrate metabolism. Effects of beta-receptor blockade on insulin secretion and peripheral insulin sensitivity in normoglycaemic patients. Eur J Clin Pharmacol 33, 273–277 (1987). https://doi.org/10.1007/BF00637561
- beta-adrenoreceptor blockers
- glucose tolerance
- insulin secretion and -sensitivity