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Research on benzimidazole derivatives

XLII. Synthesis and transformations of amides of unsaturated carboxylic acids in series of 2-amino derivatives of benzimidazole and pyridine

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Abstract

The acylation of 2-amino derivatives of benzimidazole and pyridine withβ-aryl-α, β-unsaturated carboxylic acid chlorides gave the corresponding amides, which were converted to 2-oxo derivatives of pyrimido [1,2-a]benzimidazole and pyridine by the action of bases.

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Literature cited

  1. 1.

    P. V. Tkachenko, I. I. Popov, A. M. Simonov, and Yu. V. Medvedev, Khim. Geterotsikl. Soedin., No. 7, 972 (1976).

  2. 2.

    H. Reimlinger, M. A. Peiren, and R. Merenyi, Chem. Ber.,105, 794 (1972).

  3. 3.

    D. W. Dunwell and D. Evans, J. Chem. Soc., Perkin Trans. I,15, 1588 (1973).

  4. 4.

    H. Ogura, M. Kawano, and T. Iton, Chem. Pharm. Bull. (Tokyo),21, No. 9, 2019 (1973).

  5. 5.

    G. R. Lappin, J. Org. Chem.,26, 2350 (1961).

  6. 6.

    J. J. Pachter, J. Org. Chem.,26, 4157 (1961).

  7. 7.

    A. W. Chow, D. R. Jakes, B. P. Trotter, N. M. Hall, and J. R. E. Hoover, J. Heterocycl. Chem.,10, 71 (1973).

  8. 8.

    I. I. Popov, P. V. Tkachenko, and A. M. Simonov, Khim. Geterotsikl. Soedin., No. 3, 396 (1975).

  9. 9.

    I. I. Popov, P. V. Tkachenko, and A. M. Simonov, Khim. Geterotsikl. Soedin., No. 4, 523 (1975).

  10. 10.

    B. I. Khristich, A. M. Simonov, and G. M. Suvorova, Khim. Geterotsikl. Soedin., No. 9, 1293 (1973).

  11. 11.

    Yu. N. Sheinker, A. M. Simonov, Yu. M. Yutilov, V. N. Sheinker, and E. I. Perel'shtein, Zh.Org. Khim., No. 6, 917 (1966).

  12. 12.

    E. C. Taylor and A. McKillop, J. Am. Chem. Soc.,87, 1986 (1965).

  13. 13.

    K. Nayarajan, M. D. Nair, and P. M. Pillar, Tetrahedron,23, 1683 (1967).

  14. 14.

    S. I. Lur'e, Zh. Obshch. Khim.,20, 195 (1950).

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See [1] for communication XLI.

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 90–93, January, 1978.

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Tkachenko, P.V., Simonov, A.M. & Popov, I.I. Research on benzimidazole derivatives. Chem Heterocycl Compd 14, 73–76 (1978). https://doi.org/10.1007/BF00635949

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Keywords

  • Chloride
  • Organic Chemistry
  • Amide
  • Pyridine
  • Carboxylic Acid