Advertisement

European Journal of Clinical Pharmacology

, Volume 28, Issue 1, pp 105–107 | Cite as

Effect of food ingestion on nifedipine absorption and haemodynamic response

  • K. Hirasawa
  • W. F. Shen
  • D. T. Kelly
  • G. Roubin
  • K. Tateda
  • J. Shibata
Short Communication

Summary

The absorption of nifedipine (10 mg) and haemodynamic response were studied in 10 patients with myocardial infarction before (Phase A) and after (Phase B) a standardized breakfast. In Phase A, the peak nifedipine concentration (Cmax) and maximum haemodynamic changes were found 1 h after drug administration. In Phase B, the Cmax was lower than that in phase A (43±6 vs 136±23 ng/ml,p<0.001), and both Cmax and maximum haemodynamic changes were delayed to the fourth hour after administration. Nifedipine plasma concentration correlated significantly with the percent changes in systolic and diastolic blood pressure and heart rate.

This study suggests that not only dose but also the time intervals between nifedipine administration and food intake are important in determining the haemodynamic effects.

Key words

nifedipine myocardial infarction plasma concentration haemodynamics meal effect 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Pitta P, Rava A, Biondi P (1981) High-performance liquid chromatography or nifedipine, its metabolites and photochemical degradation products. J Chromatogr 210: 516–521CrossRefGoogle Scholar
  2. 2.
    Sadanaga T, Hikida K, Tamedo K, Matsushita Y, Ohkura Y (1982) Determination of nifedipine in plasma by high-performance liquid chromatography. Chem Pham Bull 30: 3807–3809Google Scholar
  3. 3.
    Zar JH (1974) Biostatistical analysis. Englwood Cliffs, Prentice-Hall, pp 236–248Google Scholar
  4. 4.
    Jokobson P, Pedersen OL, Mikkelsen E (1979) Gas chromatographic determination of nifedipine and one of its metabolites using electron-capture detection. J Chromatogr 162: 81–87CrossRefGoogle Scholar
  5. 5.
    Foster TS, Hamann SR, Richards VR, Bryant PJ, Graves DA, McAllister RG Jr (1983) Nifedipine kinetics and bioavailability after single intravenous and oral doses in normal subjects. J Clin Pharmacol 23: 161–170PubMedGoogle Scholar
  6. 6.
    Welling PG (1977) Influence of food and diet on gastro-intestinal drug absorption: a review. J Pharmacokin et Biopharm 5: 291–334CrossRefGoogle Scholar
  7. 7.
    Horster FA (1975) Pharmacokinetics of nifedipine —14C in man. In: Hashimoto K, Kimura E, Kobayashi T (eds) First International Adalat Symposium. Tokyo University of Tokyo, pp 67–70Google Scholar

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • K. Hirasawa
    • 1
  • W. F. Shen
    • 1
  • D. T. Kelly
    • 1
    • 3
  • G. Roubin
    • 1
  • K. Tateda
    • 2
  • J. Shibata
    • 2
  1. 1.Hallstrom Institute of CardiologyRoyal Prince Alfred HospitalSydneyAustralia
  2. 2.Department of Internal MedicineAsahikawa MunicipalAsahikawa, HokkaidoJapan
  3. 3.Hallstrom Institute of CardiologyUniversity of Sydney Royal Prince Alfred HospitalCamperdownAustralia

Personalised recommendations