Acetylsalicylic acid has no effects on various isolated immune cells in vitro

  • G. Uhlenbruck
  • H. Lötzerich
  • J. Bernhardt
  • K. Rogalla

DOI: 10.1007/BF00634294

Cite this article as:
Uhlenbruck, G., Lötzerich, H., Bernhardt, J. et al. Europ. J. Appl. Physiol. (1993) 66: 473. doi:10.1007/BF00634294


In addition to the well known biological effects of acetylsalicylic acid (ASA), its stimulating effect on the immune system has recently been described. In the present study, therefore, the influence of ASA on isolated leucocytes was investigated in vitro. Various concentrations of ASA, representing therapeutic concentrations, had neither an inhibitory nor a stimulating influence on the cytotoxicity of C1316-positive cells. The phytohaemagglutinin-induced proliferation of lymphocytes and the phagocytosis activity of monocytes and neutrophilic granulocytes was similarly unaffected. These results would indicate that the immunostimulating effects already described for ASA cannot be examined in isolated leucocytes in vitro and should be attributed to an interaction of various effector cells in vivo.

Key words

Acetylsalicylic acid Phagocytes Natural killer cells Lymphocytes Biological response modifier 

Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • G. Uhlenbruck
    • 1
  • H. Lötzerich
    • 2
  • J. Bernhardt
    • 3
  • K. Rogalla
    • 4
  1. 1.Institut für ImmunbiologieUniversität KölnCologne 41Germany
  2. 2.Institut für Experimentelle MorphologieDeutsche Sporthochschule KölnCologneGermany
  3. 3.Institut für PharmakologieUniversität HamburgHamburgGermany
  4. 4.Pharmaforschungszentrum Bayer AGWuppertalGermany

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