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Self-rating data as a selecting factor in clinical trials of psychotropic drugs

  • U. Baumann
  • F. Eckmann
  • R. D. Stieglitz
Article

Summary

In psychiatry the relationship between rating by others and self-rating has been discussed again and again. The question has been raised as to the influence of complete data material (all patients with self-rating and rating by others) on results, in comparison to results where patients without self-rating are not taken into evaluation. This question was answered by conducting a double-blind study which included two pharmacologically active substances (amitriptylinoxide and trazodone) and two sub-samples of patients (patients with rating by others and self-rating, and patients with rating by others alone). The trial was performed in a total of 57 in-patients suffering from endogenous depression (ICD 296.1) who received drug treatment for 21 days. The effect was assessed multi-methodically. While no differences between the two drugs were seen in the sub-sample “self-rating and rating by others”, amitriptylinoxide proved to be superior to trazodone in the sub-sample “rating by others”. On the basis of these findings the use of rating by others and self-rating procedures will be considered.

Key words

Rating by others Self-rating Anti-depressant drugs (amitriptylinoxide, trazodone) Methodology 

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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • U. Baumann
    • 1
  • F. Eckmann
    • 1
  • R. D. Stieglitz
    • 1
  1. 1.Institut für Psychologie der Universität SalzburgSalzburgAustria

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