, Volume 56, Issue 2, pp 49–53 | Cite as

Abnormalities of hematopoesis in the acquired immunodeficiency syndrome

  • A. Ganser
Review Article


Public Health Acquire Immunodeficiency Syndrome 
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  1. 1.
    Abrams DI, Chiun EK, Brian JL, Volberding PA, Conant MA, Townsend RM (1984) Hematologic manifestations in homosexual men with Kaposi's sarcoma. Am J Clin Pathol 81: 13–18Google Scholar
  2. 2.
    Alcocoer-Varela J, Alarcon-Segovia D, Abud-Mendoza C (1985) Immunoregulatory circuits in the acquired immunodeficiency syndrome and related complex: production of and response to interleukins 1 and 2, NK finction and its enhancement by interleukin-2 and kinetics of the autologous mixed lymphocyte reaction. Clin Exp Immunol 60: 31–38Google Scholar
  3. 3.
    Amberson JB, DiCarlo EF, Metroka CE, Koizumi JH, Monradian JA (1985) Diagnostic pathology in the acquired immunodeficiency syndrome. Arch Pathol Lab Med 109: 345–351Google Scholar
  4. 4.
    Armstrong JA, Horne R (1984) Follicular dendritic cells and virus-like particles in AIDS-related lymphadenopathy. Lancet 2: 370–372Google Scholar
  5. 5.
    Barré-Sinoussi F, Chermann JC, Rey F, Nugeyre MT, Chamoret S, Gruest J, Daugnet C, Axler-Blin C, Vezinet-Brun F, Rouzioux C, Rozenbaum W, Montagnier L (1983) Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immunodeficiency syndrome (AIDS). Science 220: 868–871Google Scholar
  6. 6.
    Birx DL, Redfield RR, Tosato G (1986) Defective regulation of Epstein-Barr virus infection in patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related disorders. N Engl J Med 314: 874–879Google Scholar
  7. 7.
    Bjornson BH, McIntyre AP, Harvey JM, Tauber AI (1986) Studies of the effects of trimethoprim and sulfamethoxazole on human granulopoiesis. Am J Hematol 23: 1–7Google Scholar
  8. 8.
    Brodt KH, Helm EB, Werner A, Jötten A, Bergmann L, Klüver A, Stille W (1986) Verlaufsbeobachtungen bei Patienten aus AIDS-Risikogruppen bzw. mit LAV/HTLV-III-Infektion. In: Helm EB, Stille W, Vanek E (eds) AIDS II. Zuckschwerdt, München, pp 63–76Google Scholar
  9. 9.
    Carlo-Stella C, Ganser A, Hoelzer D (1987) Defective in vitro growth of the hemopoietic progenitor cells in the acquired immunodeficiency syndrome. J Clin Invest 80: 286–293Google Scholar
  10. 10.
    Castella A, Croxson TS, Mildvan D, Witt DH, Zalusky R (1985) The bone marrow in AIDS. A histologic, hematologic, and microbiologic study. Am J Clin Pathol 84: 425–432Google Scholar
  11. 11.
    Centers of Disease Control (1985) Revision of the case definition of acquired immunodeficiency syndrome for national reporting — United States. Ann Intern Med 103: 402–403Google Scholar
  12. 12.
    Cunningham-Rundles S, Michelis MA, Masur HJ (1983) Serum suppression of lymphocyte activation in vitro in acquired immunodeficiency disease. J Clin Immunol 3: 156–165Google Scholar
  13. 13.
    Dalgleish AG, Beverly PCL, Clapham PR, Crawford DH, Greaves MF, Weiss RA (1984) The CD 4 (T 4) antigen is an essential component of the receptor for the AIDS retrovirus. Nature 312: 763–767Google Scholar
  14. 14.
    Donahue RE, Johnson MM, Zon LI, Clark SC, Groopman JE (1987) Suppression of in vitro haematopoiesis following human immunodeficiency virus infection. Nature 326: 200–203Google Scholar
  15. 15.
    Fahey JL, Prince H, Weaver M, Groopman JE, Vissher B, Schwartz K, Getels R (1984) Quantitative changes in T helper or T suppressor/cytotoxic lymphocyte subsets that distinguish acquired immunodeficiency syndrome from other immune subset disorders. Am J Med 76: 95–100Google Scholar
  16. 16.
    Fauci AS, Macher AM, Longo DL, Lane HC, Rook AH, Masur H, Gelmann EP (1984) Acquired immunodeficiency syndrome: epidemiologic, clinical, immunologic, and therapeutic considerations. Ann Intern Med 100: 92–106Google Scholar
  17. 17.
    Fauci AS, Masur H, Gelmann EP, Markham PD, Hahn BH, Lane HC (1985) The acquired immunodeficiency syndrome: an update. Ann Intern Med 102: 800–813Google Scholar
  18. 18.
    Funke I, Hahn A, Rieber EP, Weiss E, Riethmüller G (1987) The cellular receptor of the human immunodeficiency virus is expressed on neurons and glial cells in human brain. J Exp Med 165: 1230–1235Google Scholar
  19. 19.
    Ganser A, Carlo-Stella C, Völkers B, Brandhorst I, Helm EB, Stille W, Hoelzer D (1986) Defekt des hämopoetischen Stammzellsystems bei AIDS. In: Helm EB, Stille W, Vanek E (eds) AIDS II. Zuckschwerdt, München, pp 77–80Google Scholar
  20. 20.
    Ganser A, Carlo-Stella C, Völkers B, Brodt KH, Helm EB, Hoelzer D (1987) Loss of hematopoietic progenitor cells CFU-GEMM, BFU-E, CFU-Mk, and CFU-GM in the acquired immunodeficiency syndrome (AIDS)? In: Neth R, Gallo RC, Greaves MF, Kabisch H (eds) Modern trends in human leukemia VII. Springer, Berlin Heidelberg New York, pp 175–176Google Scholar
  21. 21.
    Geller SA, Muller R, Greenberg ML, Siegal EP (1985) Acquired immunodeficiency syndrome. Distinctive features of bone marrow biopsies. Arch Pathol Lab Med 109: 138–141Google Scholar
  22. 22.
    Gottlieb MS, Groopman JE, Weinstein WM, Fahey JL, Detels R (1983) The acquired immunodeficiency syndrome. Ann Intern Med 99: 208–220Google Scholar
  23. 23.
    Greenberg ML, Hassett J, Leiderman IZ et al. (1983) Neutrophil production, release, and distribution in patients with AIDS. Cell Tissue Kinet 16: 611Google Scholar
  24. 24.
    Hammer SN, Gillis J, Groopman JE, Rose RM (1986) In vitro modification of human immunodeficiency virus infection by granulocyte-macrophage colony-stimulating factor and g-interferon. Proc Natn Acad Sci USA 83: 8734–8738Google Scholar
  25. 25.
    Heagy W, Kelley VE, Strom TB, Mayer K, Shapiro HM, Mandel R, Finberg R (1984) Decreased expression of human class II antigens on monocytes of patients with acquired immunodeficiency syndrome. J Clin Invest 74: 2089–2096Google Scholar
  26. 26.
    Ho DD, Rota TR, Hirsch MS (1986) Infection of monocytes/macrophages by human T lymphotropic virus type III. J Clin Invest 77: 1712–1715Google Scholar
  27. 27.
    Holzman RS, Walsh CM, Karpatkin S (1987) Risk for the acquired immunodeficiency syndrome among thrombocytopenic and nonthrombocytopenic homosexuell men seropositive for the human immunodeficiency virus. Ann Intern Med 106: 383–386Google Scholar
  28. 28.
    Klatzmann D, Barré-Sinoussi F, Nugeyre MT, Dauguet C, Vilmer E, Griscelli C, Brunvezinet F, Rouzioux C, Gluckman C, Chermann JC, Montagnier L (1984) Selective tropism of lymphadenopathy virus (LAV) for helper-inducer T lymphocytes. Science 225: 59–63Google Scholar
  29. 29.
    Lake JP, Lee S, Spira S (1984) Bone marrow findings in AIDS patients. Am J Clin Pathol 81: 799–800Google Scholar
  30. 30.
    Lane HC, Masur H, Edgar LC, Whalen G, Rook AH, Fauci AS (1983) Abnormalities of B-cell activation and immunoregulation in patients with the acquired immunodeficiency syndrome. N Engl J Med 309: 453–458Google Scholar
  31. 31.
    Lane HC, Masur H, Gelmann EP, Longo DL, Steis RG, Chused T, Whalen G, Edgar LC, Fauci AS (1985) Correlation between immunologic function and clinical subpopulations of patients with the acquired immunodeficiency syndrome. Am J Med 78: 417–422Google Scholar
  32. 32.
    Laurence J, Gottlieb AB, Kunkel HG (1983) Soluble suppressor factors in patients with acquired immune deficiency and its prodrome: elaboration in vitro by T lymphocyteadherent cell interactions. J Clin Invest 72: 2072–2081Google Scholar
  33. 33.
    Leiderman IZ, Greenberg ML, Adelsberg BR, Siegal FP (1984) Defective myelopoiesis in acquired immunodeficiency syndrome (AIDS). In: Gottlieb MS, Groopman JE (eds) Acquired immunodeficiency syndrome. Alan R. Liss, New York, pp 281–289Google Scholar
  34. 34.
    Montagnier L, Grust J, Chamaret S, Dauguet C, Axler C, Guetard D, Nugeyre MT, Barré-Sinoussi F, Chermann JC, Brunet JB, Klatzmann D, Gluckman JC (1984) Adaptation of lymphadenopathy-associated virus (LAV) to replication in EBV-transformed, B-lymphoblastoid cell lines. Science 225: 63–66Google Scholar
  35. 35.
    Morris L, Distenfeld A, Amorosi E, Karpatkin S (1982) Autoimmune thrombocytopenic purpura in homosexual men. Ann Intern Med 96: 714–717Google Scholar
  36. 36.
    Murphy MF, Metcalfe P, Waters AH, Linch DC, Chingsong-Popov R, Carne C, Weller IV (1985) Immune neutropenia in homosexual men (letter). Lancet I: 217–218Google Scholar
  37. 37.
    Murray HW, Rubin BY, Masur H, Roberts RB (1984) Impaired production of lymphokines and immune (gamma) interferon in the acquired immunodeficiency syndrome. N Engl J Med 310: 883–884Google Scholar
  38. 38.
    Murray HW, Gellene RA, Libby DM, Rothermel CD, Rubin BY (1985) Activation of tissue macrophages from AIDS patients: in vitro response of AIDS alveolar macrophages to lymphokines and interferon-g. J Immunol 135: 2374 to 2377Google Scholar
  39. 39.
    Osborne BM, Guarda LA, Butler JJ (1984) Bone marrow biopsies in patients with the acquired immunodeficiency syndrome. Hum Pathol 15: 1048–1053Google Scholar
  40. 40.
    Popovic M, Read-Connole E, Gallo RC (1984) T 4 positive human neoplastic cell lines susceptible to and permissive for HTLV-III. Lancet II: 1472–1473Google Scholar
  41. 41.
    Popovic M, Sarngadharan MG, Read E, Gallo RC (1984) Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS. Science 224: 497–500Google Scholar
  42. 42.
    Salahuddin SZ, Rose RM, Groopman JE, Markham PD, Gallo RC (1986) Human T lymphotropic virus type III infection of human alveolar macrophages. Blood 68: 281–284Google Scholar
  43. 43.
    Schmidts HL, Falk S, Müller H, Berger K (1986) Obduktionsbefunde beim erworbenen Immundefektsyndrom AIDS. In: Helm EB, Stille W, Vanek E (eds) AIDS II. Zuckschwerdt, München, pp 85–90Google Scholar
  44. 44.
    Schneider DR, Picker LJ (1985) Myelodysplasia in the acquired immune deficiency syndrome. Am J Clin Pathol 84: 144–152Google Scholar
  45. 45.
    Schroff RW, Gottlieb MS, Prince HE, Chai LL, Fahey JL (1983) Immunological studies of homosexual men with immunedeficiency and Kaposi's sarcoma. Clin Immunol Immunopathol 27: 300–314Google Scholar
  46. 46.
    Sei Y, Petrella RJ, Tsang P, Bekesi JG, Yokoyama MM (1986) Monocytes in AIDS. N Engl J Med 315: 1611–1612Google Scholar
  47. 47.
    Siegal FP (1984) Immune function and dysfunction in AIDS. Semin Oncol 11: 29–39Google Scholar
  48. 48.
    Siegal FP, Lopez C, Fitzgerald PA, Shah K, Baron P, Leiderman IZ, Imperato D, Landesman S (1986) Opportunistic infections in acquired immunodeficiency syndrome result from synergistic defects of both the natural and adaptive components of cellular immunity. J Clin Invest 78: 115–123Google Scholar
  49. 49.
    Smith PD, Ohura K, Masur H, Lane HC, Fauci AS, Wahl SM (1984) Monocyte function in the acquired immune deficiency syndrome: defective chemotaxis. J Clin Invest 74: 2121–2128Google Scholar
  50. 50.
    Spivak JL, Bender BS, Quinn TC (1984) Hematologic abnormalities in the acquired immune deficiency syndrome. Am J Med 77: 224–228Google Scholar
  51. 51.
    Spivak JL, Selonick SE, Quinn TC (1983) Acquired immune deficiency syndrome and pancytopenia. JAMA 250: 3084–3087Google Scholar
  52. 52.
    Stahl RE, Friedman-Kien A, Dubin R, Marmar M, Zolla-Pazner S (1982) Immunologic abnormalities in homosexual men. Relationship to Kaposi's sarcoma. Am J Med 73: 171–178Google Scholar
  53. 53.
    Stricker RB, Abrams DI, Corash L, Shuman MA (1985) Target platelet antigen in homosexual men with immune thrombocytopenia. N Engl J Med 313: 1375–1380Google Scholar
  54. 54.
    Treacy M, Lai L, Costello C, Clark A (1987) Peripheral blood and bone marrow abnormalities in patients with HIV related disease. Br J Haematol 65: 289–294Google Scholar
  55. 55.
    Völkers B, Ganser A, Carlo Stella C, Hoelzer D (in press) Decrease of in vitro colony formation of the hematopoietic progenitor cells CFU-GEMM, CFU-Mk, BFU-E, and CFU-GM in the acquired immunodeficiency syndrome. In: Najman A, Guigon M, Gorin NC, Mary JY (eds) The inhibitors of hematopoiesis. Editions INSERM, John Libbey, Paris LondonGoogle Scholar
  56. 56.
    Walsh CM, Nardi MA, Karpatkin S (1984) On the mechanism of thrombocytopenic purpura in sexually active homosexual men. N Engl J Med 311: 635–639Google Scholar
  57. 57.
    Walsh C, Krigel R, Lennette E, Karpatkin S (1985) Thrombocytopenia in homosexual patients. Ann Intern Med 103: 542–545Google Scholar
  58. 58.
    Yarchoan R, Broder S (1987) Development of antiviral therapy for the acquired immunodeficiency syndrome and related disorders: a progress report. N Engl J Med 316: 557–564Google Scholar

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • A. Ganser
    • 1
  1. 1.Abteilung für Hämatologie, Zentrum der Inneren MedizinJohann Wolfgang Goethe-UniversitätFrankfurt am Main 70Federal Republic of Germany

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