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Synthesis of ω-amino- and ω-carboxyalkylamides of N-acetylmuramoyl-L-alanyl-D-isoglutamine


The synthesis has been effected of derivatives of MDP having a spacer with an amino or carboxy group. The final stage of the synthesis was the condensation of Boc-L-Ala-D-iGln with 6-aminohexanol (followed by the two-stage replacement of the hydroxy by an azido group) or with benzyl 6-aminohexanoate.

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Additional information

Simferopol' State University. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 122–125, January–February, 1993.

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Kur'yanov, V.O., Zhelobetskaya, T.F., Zemlyakov, A.E. et al. Synthesis of ω-amino- and ω-carboxyalkylamides of N-acetylmuramoyl-L-alanyl-D-isoglutamine. Chem Nat Compd 29, 103–106 (1993).

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  • Organic Chemistry
  • Benzyl
  • Final Stage
  • Carboxy
  • Carboxy Group