European Journal of Clinical Pharmacology

, Volume 26, Issue 2, pp 265–267 | Cite as

Changes in platelet alpha2-adrenoceptors in human phaeochromocytoma

  • O. -E. Brodde
  • K. D. Bock
Short Communications

Summary

In a 44 year-old male with a surgically proven phaeochromocytoma platelet α2-adrenoceptor density, determined by3H-yohimbine binding, was only 50% of that in an age-matched control group, and plasma catecholamines were elevated. Two weeks after removal of the tumour, platelet α2-adrenoceptor density and plasma catecholamines had become normal and were not significantly different from the controls. It is concluded that endogenous catecholamines may play an important role in regulation of α2-adrenoceptor density and hence tissue sensitivity to α-adrenergic stimulation in the human being.

Key words

alpha2-adrenoceptors phaeochromocytoma catecholamines adrenoceptor regulation platelet alpha2-receptors 

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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • O. -E. Brodde
    • 1
  • K. D. Bock
    • 1
  1. 1.Biochemical Research Laboratory, Division of Renal and Hypertensive Diseases, Medizinische Klinik und PoliklinikUniversity of EssenEssenGermany

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