Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Synthesis of the amide of the C-terminal tetrapeptide of the sequence of oxytocin

  • 32 Accesses

Abstract

The synthesis has been effected of the amide of the tetrapeptide forming the sequence 6–9 of oxytocin with the use of benzyl protection of the thiol function of cysteine by two main schemes 1+3 and 2+2. The advantageousness of performing the synthesis by the 2+2 scheme has been shown. The overall yield of tetrapeptide using the method of condensation with the formation of mixed anhydrides amounted to 51% by the scheme proposed.

This is a preview of subscription content, log in to check access.

Literature cited

  1. 1.

    Zh. D. Bespalova et al., Khim. Prir. Soedin., 808 (1973); Zh. D. Bespalova et al., Zh. Obshch. Khim.,44, No. 1 (1973).

  2. 2.

    S. Ya. Miksta et al., Izv. Akad. Nauk, LatvSSR, Ser. Khim., No. 5, 618–621 (1975).

Download references

Additional information

All-Union Scientific-Research Institute of the Technology of Blood Substitutes and Hormone Preparations, Moscow. Translated from Khimiya Prirodnykh Soedinenii, Nos. 3,4, pp. 393–400, May–August, 1992.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Ivanov, A.K., Antonov, A.A. & Donetskii, I.A. Synthesis of the amide of the C-terminal tetrapeptide of the sequence of oxytocin. Chem Nat Compd 28, 344–349 (1992). https://doi.org/10.1007/BF00630256

Download citation

Keywords

  • Organic Chemistry
  • Amide
  • Cysteine
  • Thiol
  • Anhydride