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Polymorphic 4-hydroxylation of debrisoquine in chronic discoid psoriasis

Summary

1. The 4-hydroxylation of debrisoquine was measured in 42 patients with chronic discoid psoriasis. 2. The proportion of poor metabolisers (4.8%) and the median metabolic ratio (0.5) in psoriatics were similar to that reported previously in a healthy British population. 3. We conclude that the abnormality of microsomal mono-oxygenase activity which we have found in the skin and other tissues of psoriatics is not due to a generalised (non-specific) impairment of microsomal oxidation and may be enzyme specific.

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Chapman, P.H., Rawlins, M.D., Shuster, S. et al. Polymorphic 4-hydroxylation of debrisoquine in chronic discoid psoriasis. Eur J Clin Pharmacol 21, 257–258 (1981). https://doi.org/10.1007/BF00627929

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Key words

  • debrisoquine
  • psoriasis
  • chronic discoid psoriasis
  • 4-hydroxylation
  • microsomal oxidation