Primary osteogenic sarcoma: Eight-year experience with adjuvant chemotherapy

  • Gerald Rosen
  • Ralph C. Marcove
  • Andrew G. Huvos
  • Brenda I. Caparros
  • Joseph M. Lane
  • Anita Nirenberg
  • Adrienne Cacavio
  • Susan Groshen
Symposium of the Cooperative Osteosarcoma Study Group — COSS 80 A Combined Diagnostic and Therapeutic Approach to Osteosarcoma Treatment May 7, 1982 in Viena


Since October 1973, 185 patients 21 years of age or younger with primary osteogenic sarcoma of an extremity were treated with adjuvant chemotherapy. Twenty-five of the first fifty-two patients (48%) have remained free of disease for a median of 7 years. In the next chemotherapy protocol most patients had chemotherapy prior to amputation or resection, during which time the dose of high-dose methotrexate was escalated in many patients to that needed to shrink the primary tumor. For a median of 4 years 43 of 54 patients (80%) have remained free of disease. In the current protocol, the response of the primary tumor to chemotherapy with high-dose methotrexate was used to select postoperative adjuvant chemotherapy for the patient. With the latter approach 73 of 79 patients (92%) have remained continuously free of disease for a median of 2 years. This experience demonstrates the value of chemotherapy in increasing the cure rate in osteogenic sarcoma and that the response to preoperative chemotherapy can help select postoperative chemotherapy to produce an even higher potential cure rate for osteogenic sarcoma.

Key words

Osteogenic sarcoma Chemotherapy Hig-dose methotrexate 


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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • Gerald Rosen
    • 1
    • 2
  • Ralph C. Marcove
    • 3
  • Andrew G. Huvos
    • 4
  • Brenda I. Caparros
    • 1
  • Joseph M. Lane
    • 3
  • Anita Nirenberg
    • 1
    • 5
  • Adrienne Cacavio
    • 5
  • Susan Groshen
    • 6
  1. 1.The Department of PediatricsMemorial Sloan-Kettering Cancer CenterNew YorkUSA
  2. 2.The Department of MedicineMemorial Sloan-Kettering Cancer CenterNew YorkUSA
  3. 3.The Department of SurgeryMemorial Sloan-Kettering Cancer CenterNew YorkUSA
  4. 4.The Department of PathologyMemorial Sloan-Kettering Cancer CenterNew YorkUSA
  5. 5.The Department of NursingMemorial Sloan-Kettering Cancer CenterNew YorkUSA
  6. 6.The Department of BiostatisticsMemorial Sloan-Kettering Cancer CenterNew YorkUSA

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