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Is the period of the circadian oscillator in the eye ofAplysia directly homeostatically regulated?

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The effect on the circadian oscillator in the isolatedAplysia eye of a number of agents which alter Ca2+ uptake or release by internal membranes has been investigated. The period of the oscillator is increased considerably by the methyl xanthines, Li+, Mn2+, and low concentrations of La3+. The effect of La3− on the oscillator can be reversed with butacaine which also inhibits the blocking effect La3+ has on Ca2+ uptake by mitochondria. The results of this study and other recent work lead us to conclude that the period of the circadian oscillator in the isolatedAplysia eye is most likely indirectly regulated.

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circadian oscillator period


artificial sea water

8 BTcAMP :

8 benzyl-thio-cyclic adenosine monophosphate


8 parachlorophenyl-thio-cyclic guanosine monophosphate

CAP compound action potential:

CR circadian rhythm


3 isobutyl 1-methyl xanthine


standard error of the mean


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Woolum, J.C., Strumwasser, F. Is the period of the circadian oscillator in the eye ofAplysia directly homeostatically regulated?. J. Comp. Physiol. 151, 253–259 (1983). https://doi.org/10.1007/BF00623902

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  • Methyl
  • Recent Work
  • Xanthine
  • Blocking Effect
  • Methyl Xanthine