Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Accumulation of radioiodinated tyrosine derivatives in the adrenal medulla and in melanomas

  • 41 Accesses

  • 36 Citations


Because tyrosine and dopa can be regarded as precursors of adrenomedullary hormones and melanin, radioiodinated derivatives of these compounds were tested for their accumulation in the adrenal medulla and in melanomas of various animal species. The highest level of accumulation in the adrenal medulla was attained in mice and rats with iodinated β-hydroxy-α-methyltyramine, and in melanomas of mice with iodinated α-methyltyrosine. The results could not be reproduced to the same extent in other species.

This is a preview of subscription content, log in to check access.


  1. Anderson, B.G., Beierwaltes, W.H., Harrison, T.S., Ansari, A.N., Buswink, A.A., Ice, R.D.: Labeled Dopamine concentration in pheochromocytomas. J. Nucl. Med.14, 781–784, (1973)

  2. Beierwaltes, W.H., Liebermann, L.M., Varma, V.M., Counsell, R.E.: Visualizing human malignant melanoma and metastases. JAMA206, 97–102 (1968)

  3. Blois, M.S., Kallmann, R.F. The incorporation of C-14 from 3,4-Dihydroxyphenylalanine-2′-C-14 into the melanin of mouse melanomas. Cancer Res.24, 863–868 (1964)

  4. Blois, M.S.: Melanin binding properties of iodoquine. J. Invest. Derm.50, 250–253 (1968)

  5. Counsell, R.E., Smith, T.D., Diguilio, W., Beierwaltes, W.H.: Tumor localizing agents VIII-radioiodinated phenylalanine analogs. J. Pharmaceut. Sci.57, 1958–1961 (1968)

  6. Delorme, G., Pasqualini, R., Groisier, J.C., Hegesippe, M., Debaud, B., Gest, J.: Scintigraphic localization of pheochromocytomas with131I-monoiodotyrosine. Eur. J. Nucl. Med.1, 94 (1976) (Abstract)

  7. Fowler, J.S., Ansari, A. N., Atkins, H.L., Bradley-Moore, P.R., MacGregor, R.R., Wolf, A.P.: Synthesis and preliminary evaluation in animals of carrier-free11C-I-Dopamine hydrochloride: X J. Nucl. Med.14, 867–869 (1973)

  8. Hansson, E., Clark, W.G.: Studies on Dopa decarboxylase inhibitors in vivo by use of C-14-Carboxyl-labelled Dopa. Prod. Soc. Exp. Biol. Med.111, 793–798 (1962)

  9. Hempel, K., Deimel, M.: Einfluß des Dopa-Decarboxylase-Hemmers α-Methyl-Dopa auf die Umwandlung von Dopa in Melanin und Brenzcatechinamine. Naunyn-Schmiedeberg's Arch. exp. Path. u. Pharmak.246, 203–214 (1963)

  10. Hempel, K., Deimel, M.: Untersuchungen zur gezielten Strahlentherapie des Melanoms und des chromaffinen Systems durch selektive H-3-Inkorporation nach Gabe von H-3-markiertem DOPA. Strahlentherapie121, 22–45 (1963)

  11. Hoyte, R.M., Lin, S.S., Christman, D.R., Atkins, H.L.; Hauser, W., Wolf, A.P.: Organic radiopharmaceuticals labeled with short-lived nuclides III.18F-labeled phenylalanines. J. Nucl. Med.12, 280–286 (1971)

  12. Ice, R.D., Wieland, D.M., Beierwaltes, W.H., Lawton, R.G., Redmond, M.J.: Concentration of Dopamin analogs in the adrenal medulla. J. Nucl. Med.16, 1147–1151 (1975)

  13. Kloss, G., Becker, H., Niemann, E., Leven, M.: 1-(Jodhydroxyphenyl)-2-aminopropanderiviate, Verfahren zu ihrer Herstellung und diagnostisches Mittel. Patent Specification 21 45 282 (Fed. Rep. of Germany), 1974

  14. Kloss, G., Kellner, H.-M., Kötter, Chr.: Vakuum-Kontakt-Methode bei der Makroautoradiographie. Naturforsch.280, 468 (1973)

  15. Meier, D.A., Beierwaltes, W.H., Counsell, R.E.: Radioactivity from labeled precursors of melanin in mice and hamsters with malanomas. Cancer Res.27 1354–1359 (1967)

  16. Morales, J.O., Beierwaltes, W.H., Counsell, R.E., Meier, D.H.: The concentration of radioactivity from labeled Epinephrine and its precursors in the dog adrenal medulla. J. Nucl. Med.8, 800–809 (1967)

  17. Patzschke, K.: Ganztier-Autoradiographie. Münch. Med. Wschr.110, 2043–2053 (1968)

  18. Prasad, G.C., Siddiqui, M.Z., Udupa, K.N.: Autoradiographic studies on the role of adrenaline in stress by using H-3-adrenaline. Am. J. Roentg.118, 852–860 (1973)

  19. Smith, T.D.: Synthesis of radiolabeled catecholamine precursors and analogs as potential tumor diagnostic agents. Dissertation No. 9067, University of Michigan (1968)

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Kloss, G., Leven, M. Accumulation of radioiodinated tyrosine derivatives in the adrenal medulla and in melanomas. Eur J Nucl Med 4, 179–186 (1979). https://doi.org/10.1007/BF00620482

Download citation


  • Public Health
  • Melanoma
  • Tyrosine
  • Nuclear Medicine
  • Animal Species