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Objective evaluation of scintigraphic diagnosis of bone metastasis

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Abstract

Using bone scintigraphs (B.S.) from neoplasic patients, a quantitative analysis of the relation existing between objective scintigraphic signs and the diagnosis of presence or absence of bone metastases was carried out. In this way, an attempt was made to increase the specificity of the B.S. for this diagnosis. Thus, a group of signs from the B.S. was chosen and an analysis of the frequency of their presence in relation to the diagnosis of bone metastasis was carried out. For each sign, considered as discrete mathematical variables, an index arising from the following expression: Sensitivity-(1-Specificity) was calculated. In this manner, each scintigraph may be quantified by the addition of the indices which correspond to the signs present in it. The set of possible numerical values was divided into 7 intervals, each of which establishes a different degree of reliability in the diagnosis of bone metastasis. This approach permitted ROC analysis and the formation of the representative curve.

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References

  1. 1.

    Citrin DL (1977) PRoblems and limitations of bone scanning with the Tc99m-phosphates. Clin Radiol 28:97–105

  2. 2.

    Citrin DL, Hougen C, Zweibel W, Schlise S, Pruitt B, Ershler N, Davies TE, Harberg J, Cohen AJ (1981) The use of serial bone scans in assessing response of bone metastases to systemic treatment. Cancer 47:680–685

  3. 3.

    McNeil BJ (1984) Value of Bone Scanning in Neoplasic Disease. Semin Nucl Med XIV:268–276

  4. 4.

    Meisel AD, Ginzler EM, Sy WM (1981) Joints and Joint Diseases. In: Gamma Images in Benign and Metabolic Bone Diseases, ed. Wilfrido M. Sy, M.D., pp 23–50. CRC Press, Florida

  5. 5.

    Monypenny IJ, Grieve RJ, Howell A, Morrison JM (1984) The value of serial bone scanning in operable breast cancer. Br J Surg 71:466–468

  6. 6.

    Rankin D (1984) False positive Bone Scan due to rib fractures following cardiac resuscitation. Nuc Med Commun 5131:173–174

  7. 7.

    Rossing N, Munck O, Pors Nielsen S, West Andersen K (1982) What do Early Bone Scans Tell about Breast Cancer Patients? Eur Cancer Clin Oncol 7:629–636

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Correspondence to A. Allende-Riera.

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Allende-Riera, A., Hdez-Armas, J. & Oton-Sanchez, C. Objective evaluation of scintigraphic diagnosis of bone metastasis. Eur J Nucl Med 12, 482–485 (1987). https://doi.org/10.1007/BF00620470

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Key words

  • Bone scintigraphs
  • Diagnosis of bone metastasis
  • Quantitative analysis
  • ROC analysis