European Radiology

, Volume 6, Issue 1, pp 9–13 | Cite as

Iodixanol vs iopamidol in intravenous DSA of the abdominal aorta and lower extremity arteries: a comparative phase-III trial

  • R. Fischbach
  • P. Landwehr
  • K. Lackner
  • J. Ø. Nossen
  • W. Heindel
  • K. J. Berg
  • G. Eichhorn
  • T. F. Jacobsen
Original Articles Contrast media

Abstract

Iodixanol (visipaque, 320 mgI/ml) was compared with iopamidol (Solutrast, 370 mfI/ml) in a double-blind, randomized, parallel group, intravenous DSA phase-III trial for evaluation of safety and efficacy. A total of 117 patients received iodixanol (n = 60) or iopamidol (n = 57). Diagnostic efficacy was evaluated using categoric and visual analogue scales. Discomfort and adverse evenets were recorded. A total of 39 patients collected urine up to 72 h after the examination for analysis. Diagnostic efficacy and radiographic density were similar in both groups. Discomfort was milder with iodixanol. The difference between the frequency of adverse events between both groups (iodixanol = 7, iopamidol = 2) was without statistical significance. Creatinine clearance was slightly more affected by iodixanol, whereas the increase in renal excretion ofN-acetyl-beta-glucosaminidase (NAG) in the first 24 h collection period after the examination was significantly higher (p < 0.01) with iopamidol. Iodixanol was of equal diagnostic efficacy compared with iopamidol despite its reduced iodine content. Both contrast media are well suited for IV DSA.

Key words

Contrast media Comparative study Intravenous digital subtraction angiography Iodixanol Iopamidol Kidney function 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Ford KK, Newman GE, Dunnick NR (1984) The optimal contrast material for digital subtraction angiography of renal arteries: ionic or nonionic? Invest Radiol 19: 244–246Google Scholar
  2. 2.
    Jynge P, Holten T, Øksendal AN (1993) Sodium-calcium balance and cardiac function wih isotonic iodixanol. An experimental study in the isolated rat heart. Invest Radiol 28: 20–25Google Scholar
  3. 3.
    Almén T (1987) Effects of iodixanol, iopentol, iohexol and metrizoate on femoral blood flow after injection into the femoral artery of the dog. Acta Radiol (Suppl) 370: 69–72Google Scholar
  4. 4.
    Bolstad B, Borch KW, Grynne BH, Lundby B, Nossen JØ, Kloster YF, Kristoffersen DT, Andrew E (1991) Safety and tolerability of iodixanol. A dimeric, nonionic contrast medium: an emphasis on European clinical phases I and II. Invest Radiol 26: 5201–5204Google Scholar
  5. 5.
    Svaland MG, Haider T, Langseth MK, Andrew E, Hals PA (1992) Human pharmacokinetics of iodixanol. Invest Radiol 27:130–133Google Scholar
  6. 6.
    Kløw NE, Levorstad K, Berg KJ, Brodahl U, Endresen K, Kristoffersen DT, Laake B, Simonsen S, Tofte AJ, Lundby B (1993) Iodixanol in cardioangiography in patients with coronary artery disease. Tolerability, cardiac and renal effects. Acta Radiol 134: 72–77Google Scholar
  7. 7.
    Palmers Y, De Greef D, Grynne BH, Smits J, Put E (1993) A double-blind study comparing safety, tolerability and efficacy of iodixanol 320 mgI/ml and ioxaglate 320 mgI/ml in cerebral arteriography. Eur J Radiol 17: 203–209Google Scholar
  8. 8.
    Pugh ND, Sissons GR, Ruttley MS, Berg KJ, Nossen JØ, Eide H (1993) Iodixanol in femoral arteriography (phase III): a comparative double-blind parallel trial between iodixanol and iopromide. Clin Radiol 47: 96–99Google Scholar
  9. 9.
    Grynne BH, Nossen JØ, Bolstad B, Borch KW (1995) Main results of the first comparative clinical studies on Visipaque. Acta Radiol (in press)Google Scholar
  10. 10.
    Hine AL (1985) Contrast media osmolarity and plasma volume change. Acta Radiol Diagn 26: 753–756Google Scholar
  11. 11.
    Jakobsen JÅ, Nossen JØ, Morensen NP, Berg KJ (1993) Renal tubular effects of diuretics and X-ray contrast media. A comparative study of equimolar doses in healthy volunteers. Invest Radiol 28: 319–324Google Scholar
  12. 12.
    Lackner K, Köster O, Uexküll Vv, Broich H (1984) Nebenwirkungen nach hochdosierter Injektion nierengängiger Kontrastmittel. Fortschr R6ntgenstr 141: 447–452Google Scholar
  13. 13.
    Dundore RL, Silver PJ, Ezrin AM, Lee KC, Buchholz RA, van Aller G, Clas DM, Roth GM, Harnish PP, Bailey DM, Pagani D (1991) The effects of iodixanol and iopamidol on hemodynamic and cardiac electrophysiologic parameters in vitro and vivo. Invest Radiol 26: 715–721Google Scholar
  14. 14.
    Kløw NE, Mortensen E, Refsum H (1991) Left ventricular systolic and diastolic function during coronary arteriography before and after acute left ventricular failure in dogs. A comparison between iodixanol, iohexol and ioxaglate. Acta Radiol 32: 124–129Google Scholar
  15. 15.
    Gross-Fengels W, Beyer D, Fischbach R, Lanfermann H (1991) Akute Nebenwirkungen und Komplikationen der zentralvenösen DSA. Ergebnisse bei 2600 Untersuchungen. Med Klin 86: 561–565Google Scholar
  16. 16.
    Stevens JM, Al-Kutoubi A, Sheppick S, Klaveness AJ (1995) Visipaque (iodixanol) in intravenous cerebral digital subtraction angiography. Comparison with Omnipaque (iohexol). Eur Radiol (Suppl) 5: S391Google Scholar
  17. 17.
    Nakstad P (1983) Digital subtraction angiography of the carotid arteries. Acta Radiol (Suppl) 360: 89–93Google Scholar
  18. 18.
    Nossen JØ, Bach-Gansmo T, Kloster Y, Jørgensen NP (1993) Heat sensation in connection with intravenous injection od isotonic and low-osmolar X-ray contrast media and mannitol solutions. Eur Radiol 3: 46–48Google Scholar
  19. 19.
    Jørensen NP, Nossen JØ, Borch KW, Kristiansen AB, Kristoffersen DT, Lundby B, Theodorsen L (1992) Safety and tolerability of iodixanol in healthy volunteers with reference to two monomeric X-ray contrast media. Eur J Radiol 15: 252–257Google Scholar
  20. 20.
    Andersen PE, Bolstad B, Berg KJ, Justesen P, Thayssen P, Kloster YF (1993) Iodixanol and ioxaglate in cardioangiography: a double-blind randomized phase III study. Clin Radiol 48: 268–272Google Scholar

Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • R. Fischbach
    • 1
  • P. Landwehr
    • 1
  • K. Lackner
    • 1
  • J. Ø. Nossen
    • 2
  • W. Heindel
    • 1
  • K. J. Berg
    • 3
  • G. Eichhorn
    • 1
  • T. F. Jacobsen
    • 2
  1. 1.Department of Diagnostic RadiologyUniversity of CologneCologneGermany
  2. 2.Nycomed Imaging ASOsloNorway
  3. 3.RikshospitaletUniversity of OsloOsloNorway

Personalised recommendations