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Malignant papillary cystadenoma lymphomatosum

Light and electron microscopic study

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A case of malignant papillary cystadenoma lymphomatosum was investigated by light and electron microscopy. Histologically, the tumor consisted mainly of a characteristic papillary cystadenoma lymphomatosum, but the feature of epithelial components varied greatly in separate portions of the tissue; papillary adenoma-, tubular adenocarcinoma-, acinic cell tumor- or oncocytoma-like features were observed, the tumor cells showing “atypia” in major components. Numerous intracytoplasmic inclusions were found in many oncocytic cells arranged in acinar structure, and stained with PAS, AZAN or Alcian blue. Electron microscopically, large numbers of very large, swollen and closely packed mitochondria were observed in almost all the tumor cells. The intraplasmic inclusions were composed mainly of a long dense body enclosed by a single unit membrane, and the contents constituted bundles of fine filament running parallel to the longer axis. The inclusions were often observed to unite with lysosomes and to co-exist with secretory granules in the cytoplasm.

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  1. Ashley EJB (1978) Evans' Histological Appearances of Tumors. Third edition. Churchill Livingstone, Edinburgh London and New York, p 538

  2. Assor D (1974) Bilateral carcinoma of the parotid. One cancer arising in a Warthin's tumor. Am J Clin Pathol 61:270–274

  3. Cameron WR, Stenram U (1979) Adenoma of parotid gland with sebaceous and oncocytic features. Cancer 43:1429–1433

  4. Cifonelli JA, Dorfman A (1970) Properties of heparin monosulfate (Heparitin monosulfate). J Biol Chem 253:3283–3286

  5. De la Pava S, Knutson GH, Kukhtar F, Pickren JW (1965) Squamous cell carcinoma arising in Warthin's tumor of the parotid gland. First case report. Cancer 18:790–794

  6. Döbrössi L, Ronay P, Moner L (1972) Malignant papillary cystadenoma lymphomatosum. Oncology 26:457–465

  7. Fleischer I, Caselits J, Löning Th, Seifert G (1980) Histological and immunocytochemical examinations of the stromal reaction in carcinomas of the parotid gland. — Analysis of 52 cases. J Cancer Res Clin Oncol 96:193–209

  8. Foote FW, Frazell EL (1954) Tumors of the major salivary glands. Atlas of Tumor Pathology, Section IV, Fasc 11. AFIP, Washington DC, p 129

  9. Gadient SE, Kalfayan B (1975) Mucoepidermoid carcinoma arising within a Warthin's tumor. Oral Surg 40:391–398

  10. Kessler E, Koznizky IL, Schindel J (1977) Malignant Warthin's tumor. Oral Surg 43:111–115

  11. Little JE, Rickles NH (1965) Malignant papillary cystadenoma lymphomatosum. Report of a case, with a review of the literature. Cancer 18:851–856

  12. McGavran MH, Bauer WC, Ackerman LV (1960) Sebaceous lymphadenoma of the parotid salivary gland. Cancer 13:1185–1187

  13. Moosavi H, Ryan CK, Schwarts S, Donnelly JA (1980) Malignant adenolymphoma. Hum Pathol 11:80–83

  14. Ohya T, Kaneko Y (1970) Novel hyaluronidase from Streptomyces. Biochim Biophys Acta 198:607–609

  15. Rawson AJ, Horn RC (1950) Sebaceous gland and sebaceous gland-containing tumors of the parotid salivary gland. With a consideration of the histogenesis of papillary cystadenoma lymphomatosum. Surgery 27:93–101

  16. Ruebner B, Bramhall JL (1960) Malignant papillary cystadenoma lymphomatosum. Report of a case, with a brief review of the literature. Arch Pathol 69:18–125

  17. Seifert G, Heckmayr M, Donath K (1977) Carcinomas in papillary cystadenolymphomas of the parotid gland. — Definition and differential diagnosis. Zeitschr Krebsforsch 90:25–36

  18. Seifert G, Bull HG, Donath K (1980) Histologic subclassification of the cystadenolymphoma of the parotid gland. Analysis of 275 cases. Virchows Arch [Pathol Anat 388:13–38

  19. Sholley MM, Pratt NE, Sodicoff M (1981) Cystoplasmic crystalloids in irradiated rat parotid glands. J Oral Pathol 10:192–202

  20. Takenchi J, Soube M, Yoshida M, Sato E (1978) Glycosaminoglycan synthetic activity of pleomorphic adenoma, adenoid cystic carcinoma and nonneoplastic tubuloacinar cells of the salivary gland. Cancer 42:202–208

  21. Tandler B, Shipkey FH (1964) Ultrastructure of Warthin's tumor. II. Crystalloid. J Ultrastruct Res 11:306–314

  22. Thackray AC, Lucas RB (1974) Tumors of the major salivary glands. Atlas of Tumor Pathology, Second Series. Fasc 10. AFIP, Washington DC, p 40 and p 102

  23. Uchibori N, Yoshizaki S, Shamoto M, Takeuchi J (1983) An epidermoid carcinoma arising in parotid adenolymphomatous lesion with microdeposit of amyloid substance. Acta Pathol Jpn 33:141–146

  24. Wasan SM (1971) Sebaceous lymphadenoma of the parotid gland. Cancer 28:1019–1022

  25. Yamagata T, Saito H, Habuchi O, Suzuki S (1968) Purification and properties of bacterial chondroitinases and chondrosulfatase. J Biol Chem 243:1523–1535

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Correspondence to Nobuo Nakashima.

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Nakashima, N., Goto, K. & Takeuchi, J. Malignant papillary cystadenoma lymphomatosum. Vichows Archiv A Pathol Anat 399, 207–219 (1983).

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Key words

  • Malignant papillary cystadenoma lymphomatosum
  • Crystalloids