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An immunological study of germinal centres in four ophthalmic immunocytomas

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Four ophthalmic lymphoplasmacytic/lymphoplasmacytoid (LP) immunocytomas with germinal centres were reviewed histologically and studied immunologically by means of the peroxidase-antiperoxidase (PAP) method. In two cases a histological diagnosis of LP immunocytoma was made, while in the other two cases a non-Hodgkin's lymphoma could not be histologically differentiated with certainty from a pseudolymphoma or reactive process. Immunological analysis confirmed the diagnosis in the former two cases and led in one of the latter also to a diagnosis of LP immunocytoma. In the fourth case the development of LP immunocytoma out of a pseudolymphoma could be demonstrated. In the four LP immunocytomas the germinal centres showed a monoclonal pattern of immunoglobulin in one case, a polyclonal pattern in one case and a negative reaction in two cases. The role of germinal centres in relation to the development of LP immunocytoma is discussed.

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Correspondence to K. Lennert.

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Molenaar, W.M., Schwarze, E.-. & Lennert, K. An immunological study of germinal centres in four ophthalmic immunocytomas. Vichows Archiv A Pathol Anat 399, 141–148 (1983). https://doi.org/10.1007/BF00619575

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Key words

  • Ophthalmic LP immunocytoma
  • Pseudolymphoma
  • Germinal centres
  • Intracytoplasmic immunoglobulin