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European Journal of Clinical Pharmacology

, Volume 8, Issue 1, pp 15–19 | Cite as

Differential antianginal responsiveness to acebutolol

  • P. Biron
  • G. Tremblay
Originals

Summary

Six unselected males suffering from documented coronary insufficiency and grade II to III angina were submitted to graded multistage treadmill exercise test on 3 separate occasions, 3.5 hours after ingestion of either 0, 200 or 400 mg of acebutolol, a new cardioselective beta-blocker. Control measures included the random allocation to 6 balanced sequences of administration, the rigid standardisation of double-blind experimental conditions and measurements, and two types of variance analysis (latin-square and split-plot). Performance was evaluated by measuring time elapsed before occurrence of anginal pain and ECG changes, peak heart rate, peak double product (heart rate × systolic pressure), and peak oxygen consumption. The mean values for all 5 criteria showed improvement with the 200 mg dose of acebutolol, and even more so with 400 mg, but this overall effect resulted mainly from the excellent response of 3 of the patients. When patients were grouped into 2 categories of responders and non-responders, a significant Dose × Category interaction was found for all criteria. Furthermore, maximal response under acebutolol was negatively correlated with values under placebo (0 mg); this correlation reached significance for peak heart rate and peak double product. It is concluded that (a) in responders, the beneficial effect of acebutolol was significant on all 5 criteria (p<0.05), (b) patients definitely fell into 2 categories of responsiveness and (c) the sensitivity of responders was partly linked to their performance under placebo and partly to unidentified individual factors.

Key words

Exercise testing exercise protocol angina beta-blocker 

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References

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Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • P. Biron
    • 1
    • 2
  • G. Tremblay
    • 1
    • 2
  1. 1.Clinical Research Unit, Department of CardiologyHôpital du Sacré-CoeurMontréalCanada
  2. 2.the Departments of Pharmacology and MedicineUniversité de MontréalMontréalCanada

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